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IL15 — LEP
Text-mined interactions from Literome
Maruna et al., Vnitr Lek 2001
(Acute-Phase Reaction...) :
Leptin mediates at least partly the anorectic effect of the tumour necrosis factor and
interleukin 1 during inflammation
Li et al., Gastroenterology 2002
(Fatty Liver) :
Leptin increases the hepatic expression of
IL-15 in ob/ob mice and partially replenishes their hepatic CD4 positive natural killer cells ...
Leptin deficiency increases hepatic IL-12 and
reduces hepatic
IL-15 expression
Quinton et al., Am J Reprod Immunol 2003
:
The
effect of
leptin on cell growth and on the production of cytokines [Leukaemia Inhibitory Factor (LIF),
interleukin 6 and tumour necrosis factor-alpha ] and matrix metalloproteinases ( MMP ) ( MMP2 and MMP-9 ) was also investigated
Frisullo et al., J Clin Immunol 2004
(Multiple Sclerosis, Relapsing-Remitting) :
Our data showed that
leptin induced tumor necrosis factor-alpha,
interleukin-6 , and interleukin-10 production by PBMCs of patients in an acute phase of disease but not in patients in a stable phase or in healthy controls
Almendro et al., Int J Mol Med 2009
:
Moreover,
IL-15 promoted a decrease in both
leptin mRNA expression and lipid accumulation, as estimated by Red Oil O staining
Granowitz et al., Biochem Biophys Res Commun 1997
(Inflammation) :
When considered in the context of animal studies showing that
interleukin-1 and tumor necrosis factor-alpha
induce leptin and ob mRNA, these results suggest that pro-inflammatory cytokines induce ob gene transcription in vivo via secondary mediators such as transforming growth factor-beta