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IL18 — TLR2
Text-mined interactions from Literome
Iwadou et al., J Int Med Res 2002
(Gram-Negative Bacterial Infections...) :
The results suggest that gabexate mesilate induced inhibition of tumour necrosis factor-alpha (TNF-alpha) and
interleukin-18 (IL-18) production in LPS stimulated PBMCs is
due to the inhibition of the nuclear factor-kappa B activation pathway and/or inhibition of the processing pathway of pro-TNF-alpha and pro-IL-18, not to down-regulation of
TLR-2 or TLR-4
Matsumura et al., Immunology 2003
:
TRAF6-NF-kappaB pathway is essential for
interleukin-1 induced
TLR2 expression and its functional response to TLR2 ligand in murine hepatocytes
Oshikawa et al., Biochem Biophys Res Commun 2003
(Lung Diseases) :
The results demonstrated three patterns of gene expression : the
TLR2 and myeloid differentiation factor 88 ( MyD88 ) gene expressions were induced in AM in
response to lipopolysaccharide (LPS),
interleukin (IL)-1beta , or tumor necrosis factor-alpha or in the lung tissue of an LPS induced acute lung injury model ; the gene expressions of TLR1, -3, -6, CD14, and MD2 were unchanged ; and the TLR4 and TLR5 gene expressions were downregulated in AM following inflammatory stimuli
Netea et al., J Immunol 2004
(Chlamydophila Infections) :
Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88 dependent,
TLR2- and TLR4 independent
induction of
IL-18 release
Kramer et al., J Leukoc Biol 2006
(Crohn Disease) :
Moreover, they lack MDP induced enhancement of
TLR mediated tumor necrosis factor alpha,
interleukin (IL)-12 , and IL-10 production, which is observed in control DC with intact NOD2
Ozören et al., J Immunol 2006
:
Distinct
roles of
TLR2 and the adaptor ASC in
IL-1beta/IL-18 secretion in response to Listeria monocytogenes
Li et al., J Immunol 2007
:
Alum induced IL-1beta and
IL-18 production was not
due to enhancement of
TLR signaling but rather reflected caspase-1 activation and in mouse dendritic cells occurred in a MyD88 independent fashion
Lee et al., J Parasitol 2010
:
We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether
TLR and MUC expression is
regulated by interferon (IFN)-gamma,
interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Han et al., Vet Microbiol 2010
:
Involvement of
TLR21 in baculovirus induced
interleukin-12 gene expression in avian macrophage-like cell line HD11
Piconi et al., AIDS 2010
(HIV Infections) :
Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression,
interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V,
activation of caspases 8 and 9,
Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed ... Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression,
interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V,
activation of caspases 8 and 9,
Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed
Chung et al., J Infect Dis 2010
(Hepatitis C, Chronic) :
Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of
interleukin 17 by naive CD4 ( + ) T cells in the
presence of
TLR ligands
Hanamsagar et al., Trends Immunol 2012
:
TLR signaling
triggers the transcriptional activation of
pro-interleukin-1ß ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome ...
TLR signaling
triggers the transcriptional activation of pro-interleukin-1ß ( pro-IL-1ß ) and
pro-IL-18 that are processed into their active forms by the inflammasome
Som et al., Clinical and vaccine immunology : CVI 2012
(Disease Models, Animal...) :
Anti-inflammatory SMAMPs prevented the induction of tumor necrosis factor (TNF),
interleukin 6 (IL-6), and IL-10 in
response to S. aureus or LTA, but no other
TLR2 ligands
Miura et al., Hepatology 2013
(Fatty Liver...) :
Here we show that both
TLR2 and palmitic acid are
required for activation of the inflammasome,
interleukin (IL)-1a , and IL-1ß, resulting in the progression of NASH
Li et al., eLife 2012
:
A sequence containing 13 nucleotides near the active site of 23S rRNA ribozyme, which catalyzes peptide bond synthesis, was both necessary and sufficient to trigger
TLR13 dependent
interleukin-1ß production
Koblansky et al., Immunity 2013
(Genetic Predisposition to Disease...) :
Toll-like receptor 11 ( TLR11 ) recognizes T. gondii profilin ( TgPRF ) and is
required for
interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice
Schamber-Reis et al., J Biol Chem 2013
(Disease Resistance...) :
Altogether, our results indicate the redundant and essential
role of nucleic acid sensing TLR3,
TLR7 and TLR9 in inducing
interleukin 12, development of a T1 response, and resistance to L. major infection in resistant C57BL/6 mice
Dotson et al., J Biol Chem 2013
(Tularemia) :
We demonstrate that muted IL-1ß and
IL-18 responses generated in macrophages infected with F. tularensis live vaccine strain ( LVS ) or the virulent SchuS4 strain are
due to a predominant suppressive effect on
TLR2 dependent signal 1