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IL1A — TIMP1

Text-mined interactions from Literome

Grønning et al., Biol Reprod 2000 (Calcium Signaling...) : TIMP-1 was not up-regulated by either 8-CPTcAMP or interleukin-1alpha in peritubular cells
Kut-Lasserre et al., J Periodontol 2001 (Periodontitis) : As anticipated, IL-1beta induced a marked release of MMP-2, MMP-3, and TIMP-1 , but no variation for TIMP-2 was seen
Kishida et al., Fetal Diagn Ther 2003 (Obstetric Labor, Premature) : The levels of interleukin (IL) 1alpha , IL-1beta, IL-6, IL-8, matrix metalloproteinase (MMP) 1, MMP-2, MMP-9, tissue inhibitors of matrix metalloproteinase ( TIMP ) 1, TIMP-2, granulocyte elastase, and fetal fibronectin in cervical diluted specimens were measured by immunoassay, and the uterine cervix was assessed by transvaginal ultrasonography
Hirata et al., Biol Reprod 2003 : The production of TIMP-1 in BT-1 cells was also augmented by IL-1alpha , TNFalpha, and HGF at the level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate
Emonard et al., Matrix 1992 : These results strongly suggest that IL-6 is not involved in the extracellular matrix breakdown, either directly by acting on cell production of MMPs or TIMP, or indirectly by modulating the effect of IL-1 on the synthesis of MMPs and TIMP
Smith et al., Br J Ophthalmol 2004 : IL-1alpha and LPS had no effect on MMP/TIMP production by cultured corneal epithelial cells and keratocytes
Wisithphrom et al., J Endod 2006 : IL-1 alpha increased the secreted protein level of TIMP-1 , while only slightly affected the level of TIMP-2
Takahashi et al., J Biol Chem 1991 : IL-1 significantly augmented the production of proMMP-1 ( vertebrate procollagenase ), proMMP-3 ( prostromelysin ), and TIMP without detectable changes in the intracellular level of cAMP ... In contrast, Bt2cAMP slightly enhanced the IL-1 induced production of TIMP
MacNaul et al., J Biol Chem 1990 (Arthritis, Rheumatoid) : The results revealed that 1 ) stromelysin and collagenase were not always coordinately expressed ; 2 ) IL-1 was more potent than TNF or PMA in the induction of stromelysin expression ; 3 ) neither IL-1 nor TNF significantly affected TIMP expression ; 4 ) PMA induced both metalloproteinase and TIMP expression ; and 5 ) the combination of IL-1 plus TNF had a synergistic effect on stromelysin expression
Chang et al., Rheumatol Int 2007 (Chondrosarcoma) : Activin A had no effect on the production of sGAG, IL-1ra, or TIMP-1, although it suppressed the induction of TIMP-1 and IL-1ra by IL-1alpha
Weise et al., J Endocrinol 2008 : In the present study, the effect of insulin resistance inducing and proinflammatory interleukin (IL)-1 beta on TIMP-1 gene expression and secretion was investigated in 3T3-L1 adipocytes ... Thus, IL-1 beta induced TIMP-1 secretion in a dose dependent manner with maximal 3.5-fold upregulation seen at 0.67 ng/ml IL-1 beta relative to untreated cells
Turner et al., Matrix Biol 2010 : IL-1a increased expression of TIMP-1 slightly, but not TIMP-2
Sato et al., Biochem Biophys Res Commun 1990 : IL-6 did not modulate the expression of MMPs by these fibroblasts, but the production of TIMP was enhanced by IL-6 in a dose dependent manner, whereas IL-1 stimulated the production of both MMPs and TIMP ... The combination of IL-6 and IL-1 further augmented IL-1 induced MMPs and TIMP production ... The results provide the first evidence that IL-6 participates in the catabolism of the extracellular matrix components by modulating the effects of IL-1 on MMPs and TIMP synthesis as well as its direct effects on the synthesis of TIMP by connective tissue cells
Ito et al., FEBS Lett 1990 : In contrast, human recombinant interleukin-1 alpha ( hr IL-1, 10 ng/ml ) coordinately induced these enzymes and TIMP production ... Furthermore, the fact that TNF and IL-1 differently controlled the production of TIMP suggests that the signal pathway of TNF for TIMP production is different from that of IL-1
Kapral et al., Int J Colorectal Dis 2012 (Colonic Neoplasms...) : Proinflammatory cytokine IL-1ß upregulates MMP and TIMP mRNAs expression in colon cancer epithelial cells Caco-2
Zhang et al., International journal of ophthalmology 2012 : Celecoxib can also inhibit the IL-1ß induced increases in the TIMP1 , 2
Fields et al., PloS one 2013 : In this report we sought to identify key signaling pathways necessary for IL-1ß mediated astrocyte TIMP-1 expression and their interaction with C/EBPß ... The p38 kinase (p38K) inhibitors partially blocked both IL-1ß induced astrocyte TIMP-1 expression and C/EBPß expression ... The ERK1/2-selective inhibitor abrogated IL-1ß mediated increases in TIMP-1 promoter activity ... Our data demonstrate that ERK1/2 activation is critical for IL-1ß mediated astrocyte TIMP-1 expression ... Furthermore, p38K activation contributes to IL-1ß induced astrocyte TIMP-1 and C/EBPß expression ... These data suggest that ERK1/2 signals downstream of C/EBPß to facilitate IL-1ß induced astrocyte TIMP-1 expression
Zhou et al., International journal of ophthalmology 2013 : LXA4 could also inhibit the IL-1ß induced increases in TIMP-1 , -2
Wei et al., Spine (Phila Pa 1976) 2013 : IL-1 moderately upregulated aggrecan and TIMP-1 expression, ERK inhibition had no significant effect on aggrecan expression but decreased TIMP-1 expression in the presence of IL-1 ... ERK inhibition reversed the changes of protein expression of MMP-3, MMP-13, TIMP-1 , aggrecan and collagen II induced by IL-1
Martel-Pelletier et al., Lab Invest 1994 (Arthritis, Rheumatoid...) : The differential regulation of metalloprotease and TIMP syntheses by IL-1 suggests that this cytokine, during inflammatory conditions, may promote cartilage degradation by creating an imbalance between the level of these enzymes and their inhibitors
Samples et al., Invest Ophthalmol Vis Sci 1993 : When added together, dexamethasone antagonizes the interleukin-1 alpha induced increase of stromelysin, gelatinase B, and TIMP1 in a dose dependent manner
Takahashi et al., Biochim Biophys Acta 1993 : The suppressive effect of H-7 and staurosporine on the IL-1 induced production of proMMPs-1 and -3 and TIMP-1 resulted from the decrease in the steady-state levels of their mRNAs ... These results indicate that protein kinase C mediates the IL-1 induced production of proMMPs-1 and -3 and TIMP-1 at the pretranslational level in human uterine cervical fibroblasts
So et al., Nihon Sanka Fujinka Gakkai Zasshi 1993 (Chorioamnionitis...) : 2 ) IL-1 stimulated the production of MMPs, TIMP and PGE2 ... 3 ) The combination of IL-1 and TNF alpha further augmented IL-1 induced production of MMPs, but IL-1 induced TIMP was suppressed by TNF alpha treatment
Cawston et al., Biochim Biophys Acta 1996 : IL-4, especially in the presence of IL-1 , increased TIMP secretion by bovine nasal cartilage in culture
Takahashi et al., Inflamm Res 1997 (Arthritis, Rheumatoid) : RhIL-1 beta augments the production of TIMP-1 and proMMP-1 in synovial fibroblasts from RA patients, and this IL-1 induced production of TIMP-1 and proMMP-1 was further enhanced by treatment with the cyclooxygenase inhibitors, indomethacin and diclofenac
Alexander et al., Curr Eye Res 1998 : A phorbol mitogen ( TPA ), and TNF alpha and beta, interleukin-1 alpha and PDGF BB stimulate gelatinase B, stromelysin, interstitial collagenase and TIMP-1 expression, while having negligible effects on gelatinase A expression ; TIMP-2 levels are reduced by TNF but not affected by the other treatments
Zhang et al., J Immunol 1998 : Th2 cytokines, such as IL-4, inhibited the induction of MMPs and TIMP-1 by TNF-alpha, GM-CSF, and IL-1