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IL23A — TYK2

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL23-mediated signaling events: STAT3 (STAT3) → IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2) (modification, collaborate)
  Parham et al., J Immunol 2002, Cho et al., J Immunol 2006
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL23-mediated signaling events: PI3K complex (PIK3CA-PIK3R1) → IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2) (modification, activates)
  Parham et al., J Immunol 2002, Cho et al., J Immunol 2006
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL23-mediated signaling events: STAT1 (STAT1) → IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2) (modification, collaborate)
  Parham et al., J Immunol 2002
  Evidence: physical interaction
• NCI Pathway Database IL23-mediated signaling events: SOCS3 (SOCS3) → IL23/IL23R/JAK2/TYK2/SOCS3 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2-SOCS3) (modification, collaborate)
  Chen et al., Proc Natl Acad Sci U S A 2006
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL23-mediated signaling events: SOCS3 (SOCS3) → IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2) (modification, collaborate)
  Chen et al., Proc Natl Acad Sci U S A 2006
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL23-mediated signaling events: IL23/IL23R/JAK2/TYK2/SOCS3 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2-SOCS3) → IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2) (modification, collaborate)
  Chen et al., Proc Natl Acad Sci U S A 2006
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL23-mediated signaling events: IL2 (IL2) → IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2) (transcription, activates)
  Parham et al., J Immunol 2002
• NCI Pathway Database IL23-mediated signaling events: IL18/IL18R complex (IL18-IL18R1-IL18RAP) → IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2) (transcription, activates)
  Parham et al., J Immunol 2002
• NCI Pathway Database IL23-mediated signaling events: STAT4 (STAT4) → IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2) (modification, collaborate)
  Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002
  Evidence: assay, physical interaction
• NCI Pathway Database IL23-mediated signaling events: STAT3 (STAT3) → IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2) (modification, collaborate)
  Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002
  Evidence: assay, physical interaction
• NCI Pathway Database IL23-mediated signaling events: STAT4 (STAT4) → IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2) (modification, collaborate)
  Parham et al., J Immunol 2002
  Evidence: physical interaction
• NCI Pathway Database IL23-mediated signaling events: IL23 complex (IL23A-IL12B) → IL12Rbeta1/TYK2 complex (IL12RB1-TYK2) (modification, collaborate)
  Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002, Zou et al., J Biol Chem 1997
  Evidence: physical interaction, other species
• NCI Pathway Database IL23-mediated signaling events: IL23 complex (IL23A-IL12B) → IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2) (modification, collaborate)
  Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002, Zou et al., J Biol Chem 1997
  Evidence: physical interaction, other species
• NCI Pathway Database IL23-mediated signaling events: IL12Rbeta1/TYK2 complex (IL12RB1-TYK2) → IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2) (modification, collaborate)
  Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002, Zou et al., J Biol Chem 1997
  Evidence: physical interaction, other species
• NCI Pathway Database IL23-mediated signaling events: IL23R/JAK2 complex (IL23R-JAK2) → IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2) (modification, collaborate)
  Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002, Zou et al., J Biol Chem 1997
  Evidence: physical interaction, other species
• NCI Pathway Database IL23-mediated signaling events: IFN-gamma (IFNG) → IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2) (transcription, inhibits)
  Langrish et al., J Exp Med 2005, Harrington et al., Nat Immunol 2005
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL23-mediated signaling events: STAT5A (STAT5A) → IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2) (modification, collaborate)
  Parham et al., J Immunol 2002
  Evidence: physical interaction

Text-mined interactions from Literome

Tokumasa et al., Blood 2007 : Expression of Tyk2 in dendritic cells is required for IL-12, IL-23 , and IFN-gamma production and the induction of Th1 cell differentiation
Paradowska-Gorycka et al., Scand J Immunol 2010 (Arthritis, Rheumatoid...) : IL-23 binding to an IL-23 receptor expressed on dendritic cells, macrophages and monocytes triggers the activation of Jak2 and Tyk2 , which in turn phosphorylates STAT1, STAT3, STAT4 and STAT5 as well as induce formation of STAT3-STAT4 heterodimers