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IL2RG — IL7

Pathways - manually collected, often from reviews:

• KEGG Cytokine-cytokine receptor interaction: IL7 → Complex of IL2RG-IL7R (protein-protein, activation)
• Reactome Reaction: IL2RG → IL7 (reaction) Kondo et al., Science 1994*, Noguchi et al., Science 1993*
• Reactome Reaction: IL2RG → IL7 (indirect_complex) Kondo et al., Science 1994*, Noguchi et al., Science 1993*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: IL7 — IL2RG Noguchi et al., Science 1993*
• IRef Bind_translation Interaction: IL7 — IL2RG (coimmunoprecipitation) Noguchi et al., Science 1993*
• IRef Bind_translation Interaction: IL7 — IL2RG (experimental interaction detection) Noguchi et al., Science 1993*
• IRef Dip Interaction: IL7 — IL2RG (physical association, biochemical) Kondo et al., Science 1994*
• IRef Dip Interaction: IL7 — IL2RG (physical association, fluorescent resonance energy transfer) Damjanovich et al., Proc Natl Acad Sci U S A 1997*
• IRef Hprd Interaction: IL7 — IL2RG (in vitro) Cosenza et al., Cell Signal 2002*, Kroemer et al., Protein Eng 1996*
• IRef Hprd Interaction: IL7 — IL2RG (in vivo) Cosenza et al., Cell Signal 2002*, Kroemer et al., Protein Eng 1996*
• IRef Innatedb Interaction: Complex of IL2RG-IL7R-IL7 (unknown, -) Noguchi et al., Science 1993*
• IRef Intact Interaction: IL7 — IL2RG (physical association, anti bait coimmunoprecipitation) Noguchi et al., Science 1993*
• IRef Ophid Interaction: IL7 — IL2RG (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Olosz et al., J Biol Chem 2000 (Severe Combined Immunodeficiency...) : Using a model based site directed mutagenesis strategy, we have identified residues of the mouse gammac extracellular domain that are required for normal gammac dependent enhancement of IL-2 and IL-7 binding
Ginn et al., Hum Mutat 2004 (Genetic Diseases, X-Linked...) : Atypical phenotypes have also been described, but relatively little is known about the mechanisms by which the underlying mutations impair gammac dependent interleukin receptor signalling to produce these disease variants
Sasson et al., J Infect Dis 2006 (Disease Progression...) : In vitro, exogenous IL-7 rapidly down-regulated cell-surface CD127 expression, but not CD132 expression, whereas subsequent reexpression required active protein synthesis
Hacein-Bey et al., Blood 1998 (Severe Combined Immunodeficiency) : gammac gene transfer in the presence of stem cell factor, FLT-3L, interleukin-7 (IL-7) , IL-1, and IL-15 cytokines restores T-cell differentiation from gammac ( - ) X-linked severe combined immunodeficiency hematopoietic progenitor cells in murine fetal thymic organ cultures