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IL4R — JAK1

Pathways - manually collected, often from reviews:

• BioCarta il 4 signaling pathway: IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4) → IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R) (modification, collaborate)
  
• BioCarta il 4 signaling pathway: IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4) → SHC (SHC1) (modification, activates)
• BioCarta il 4 signaling pathway: IRS1/2/GRB2 complex (GRB2) → IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4) (modification, collaborate)
  
• BioCarta il 4 signaling pathway: IRS1/2/GRB2 complex (GRB2) → IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R) (modification, collaborate)
  
• BioCarta il 4 signaling pathway: IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4) → IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R) (modification, collaborate)
  
• BioCarta il 4 signaling pathway: IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4) → GRB2 (modification, collaborate)
• BioCarta il 4 signaling pathway: IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R) → GRB2 (modification, collaborate)
• BioCarta il 4 signaling pathway: IL-4 (IL4) → IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (JAK3-JAK1-IL2RG-IL4R) (modification, collaborate)
  
• BioCarta il 4 signaling pathway: IL-4 (IL4) → IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R) (modification, collaborate)
  
• BioCarta il 4 signaling pathway: IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (JAK3-JAK1-IL2RG-IL4R) → IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R) (modification, collaborate)
  
• KEGG Jak-STAT signaling pathway: CNTFR/CRLF2/CSF2RA/CSF2RB/CSF3R/EPOR/GHR/IFNAR1/IFNAR2/IFNGR1/IFNGR2/IFNLR1/IL10RA/IL10RB/IL11RA/IL12RB1/IL12RB2/IL13RA1/IL13RA2/IL15RA/IL20RA/IL20RB/IL21R/IL22RA1/IL22RA2/IL23R/IL2RA/IL2RB/IL2RG/IL3RA/IL4R/IL5RA/IL6R/IL6ST/IL7R/IL9R/LEPR/LIFR/MPL/OSMR/PRLR → JAK1/JAK2/JAK3/TYK2 (protein-protein, phosphorylation)
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-PTPN6) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, inhibits)
  Kashiwada et al., J Immunol 2001, Hanson et al., J Biol Chem 2003, Chen et al., J Immunol 2004, Pernis et al., Proc Natl Acad Sci U S A 1995, Quelle et al., Mol Cell Biol 1995, Hou et al., Science 1994, Shimoda et al., Nature 1996, Haque et al., J Biol Chem 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: BCL6 (BCL6) → IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2) (T-helper 2 cell differentiation, inhibits)
  Wurster et al., Mol Cell Biol 2002, Swain et al., J Immunol 1990, Shimoda et al., Nature 1996, Kaplan et al., Immunity 1996, Dent et al., Science 1997, Dent et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2) → STAT6 (dimer) complex (STAT6) (T-helper 2 cell differentiation, activates)
  Wurster et al., Mol Cell Biol 2002, Swain et al., J Immunol 1990, Shimoda et al., Nature 1996, Kaplan et al., Immunity 1996, Dent et al., Science 1997, Dent et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL4-mediated signaling events: ETS1 (ETS1) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Travagli et al., J Biol Chem 2004
  Evidence: physical interaction
• NCI Pathway Database IL4-mediated signaling events: STAT6 (dimer) complex (STAT6) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Travagli et al., J Biol Chem 2004
  Evidence: physical interaction
• NCI Pathway Database IL4-mediated signaling events: SHP1 (PTPN6) → IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-PTPN6) (modification, collaborate)
  Kashiwada et al., J Immunol 2001, Imani et al., J Biol Chem 1997
  Evidence: assay, physical interaction
• NCI Pathway Database IL4-mediated signaling events: SHP1 (PTPN6) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Kashiwada et al., J Immunol 2001, Imani et al., J Biol Chem 1997
  Evidence: assay, physical interaction
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-PTPN6) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Kashiwada et al., J Immunol 2001, Imani et al., J Biol Chem 1997
  Evidence: assay, physical interaction
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Jiang et al., J Immunol 2001, Wurster et al., Mol Cell Biol 2002, Sun et al., Nature 1995, Izuhara et al., Blood 1996
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-IRS1) → IRS1 (IRS1) (modification, collaborate) Johnston et al., J Biol Chem 1995, Keegan et al., Cell 1994
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-IRS1) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Johnston et al., J Biol Chem 1995, Keegan et al., Cell 1994
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL4-mediated signaling events: IRS1 (IRS1) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Johnston et al., J Biol Chem 1995, Keegan et al., Cell 1994
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL4-mediated signaling events: GRB2 (GRB2) → IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D-GRB2) (modification, collaborate)
  Wery et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database IL4-mediated signaling events: GRB2 (GRB2) → IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D) (modification, collaborate)
  Wery et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D-GRB2) → IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D) (modification, collaborate)
  Wery et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1) → SOCS1 (SOCS1) (modification, collaborate) Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Obiri et al., J Biol Chem 1995, Murata et al., J Immunol 1996, Obiri et al., J Immunol 1997, Miloux et al., FEBS Lett 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1) → IL4/IL4R/JAK1/IL13RA1/JAK2 complex (IL4-IL4R-JAK1-IL13RA1-JAK2) (modification, collaborate)
  Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Obiri et al., J Biol Chem 1995, Murata et al., J Immunol 1996, Obiri et al., J Immunol 1997, Miloux et al., FEBS Lett 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1) → IL13RA1/JAK2 complex (IL13RA1-JAK2) (modification, collaborate)
  Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Obiri et al., J Biol Chem 1995, Murata et al., J Immunol 1996, Obiri et al., J Immunol 1997, Miloux et al., FEBS Lett 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL4-mediated signaling events: SOCS1 (SOCS1) → IL4/IL4R/JAK1/IL13RA1/JAK2 complex (IL4-IL4R-JAK1-IL13RA1-JAK2) (modification, inhibits)
  Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Obiri et al., J Biol Chem 1995, Murata et al., J Immunol 1996, Obiri et al., J Immunol 1997, Miloux et al., FEBS Lett 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL13RA1/JAK2 complex (IL4-IL4R-JAK1-IL13RA1-JAK2) → IL13RA1/JAK2 complex (IL13RA1-JAK2) (modification, collaborate)
  Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Obiri et al., J Biol Chem 1995, Murata et al., J Immunol 1996, Obiri et al., J Immunol 1997, Miloux et al., FEBS Lett 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1) → IL4 (IL4) (modification, collaborate) Kondo et al., Science 1993*, Russell et al., Science 1993*
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1) → IL4R/JAK1 complex (IL4R-JAK1) (modification, collaborate)
  Kondo et al., Science 1993*, Russell et al., Science 1993*
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: IL4 (IL4) → IL4R/JAK1 complex (IL4R-JAK1) (modification, collaborate)
  Kondo et al., Science 1993*, Russell et al., Science 1993*
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/FES complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES) → IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2) (modification, collaborate)
  Jiang et al., J Immunol 2001, Johnston et al., J Biol Chem 1995, Sun et al., Nature 1995
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/FES complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES) → IRS2 (IRS2) (modification, collaborate) Jiang et al., J Immunol 2001, Johnston et al., J Biol Chem 1995, Sun et al., Nature 1995
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2) → IRS2 (IRS2) (modification, collaborate) Jiang et al., J Immunol 2001, Johnston et al., J Biol Chem 1995, Sun et al., Nature 1995
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1) → SOCS5 (SOCS5) (modification, collaborate) Seki et al., Proc Natl Acad Sci U S A 2002, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1) → IL2R gamma/JAK3 complex (IL2RG-JAK3) (modification, collaborate)
  Seki et al., Proc Natl Acad Sci U S A 2002, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Seki et al., Proc Natl Acad Sci U S A 2002, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: SOCS5 (SOCS5) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, inhibits)
  Seki et al., Proc Natl Acad Sci U S A 2002, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: IL2R gamma/JAK3 complex (IL2RG-JAK3) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Seki et al., Proc Natl Acad Sci U S A 2002, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: SHIP (INPP5D) → IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-INPP5D) (modification, collaborate)
  Kashiwada et al., J Immunol 2001, Zamorano et al., J Immunol 1998
  Evidence: physical interaction
• NCI Pathway Database IL4-mediated signaling events: SHIP (INPP5D) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Kashiwada et al., J Immunol 2001, Zamorano et al., J Immunol 1998
  Evidence: physical interaction
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-INPP5D) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Kashiwada et al., J Immunol 2001, Zamorano et al., J Immunol 1998
  Evidence: physical interaction
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/Dok-R complex (IL4-IL4R-JAK1-IL2RG-JAK3-DOK2) → Dok-R (DOK2) (modification, collaborate) Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/Dok-R complex (IL4-IL4R-JAK1-IL2RG-JAK3-DOK2) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL4-mediated signaling events: Dok-R (DOK2) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL4-mediated signaling events: STAT6 (dimer) complex (STAT6) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Sherman et al., J Immunol 1999
  Evidence: physical interaction
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL13RA1/JAK2 complex (IL4-IL4R-JAK1-IL13RA1-JAK2) → STAT6 (STAT6) (modification, activates) Hou et al., Science 1994, Murata et al., J Immunol 1996
  Evidence: mutant phenotype
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-IRS1) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Johnston et al., J Biol Chem 1995, Sun et al., Nature 1995
  Evidence: assay, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1) → SOCS1 (SOCS1) (modification, collaborate) Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1) → IL2R gamma/JAK3 complex (IL2RG-JAK3) (modification, collaborate)
  Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: SOCS1 (SOCS1) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, inhibits)
  Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: IL2R gamma/JAK3 complex (IL2RG-JAK3) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: STAT5 (STAT5A/STAT5B) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Mora et al., J Immunol 2001
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/FES complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES) → FES (FES) (modification, collaborate) Jiang et al., J Immunol 2001
  Evidence: physical interaction
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/FES complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Jiang et al., J Immunol 2001
  Evidence: physical interaction
• NCI Pathway Database IL4-mediated signaling events: FES (FES) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Jiang et al., J Immunol 2001
  Evidence: physical interaction
• NCI Pathway Database IL4-mediated signaling events: CD40LG (CD40LG) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (transcription, activates)
  Gupta et al., J Exp Med 1999
• NCI Pathway Database IL4-mediated signaling events: SHIP (INPP5D) → IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D) (modification, collaborate)
  Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
  Evidence: physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: SHIP (INPP5D) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
  Evidence: physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D) → SHC (SHC1) (modification, collaborate) Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
  Evidence: physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
  Evidence: physical interaction, other species
• NCI Pathway Database IL4-mediated signaling events: SHC (SHC1) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
  Evidence: physical interaction, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: IL4R — JAK1 Usacheva et al., J Immunol 2002*
• IRef Bind_translation Interaction: IL4R — JAK1 (affinity chromatography technology) Usacheva et al., J Immunol 2002*
• IRef Biogrid Interaction: JAK1 — IL4R (physical association, affinity chromatography technology) Seki et al., Proc Natl Acad Sci U S A 2002
• IRef Biogrid Interaction: JAK1 — IL4R (direct interaction, pull down) Usacheva et al., J Immunol 2002*
• IRef Hprd Interaction: JAK1 — IL4R (in vitro) Usacheva et al., J Immunol 2002*
• IRef Hprd Interaction: JAK1 — IL4R (in vivo) Usacheva et al., J Immunol 2002*
• IRef Innatedb Interaction: IL4R — JAK1 (unknown, -) Usacheva et al., J Immunol 2002*
• IRef Innatedb Interaction: Complex of JAK1-IL4R-JAK1 (unknown, -) Roy et al., J Leukoc Biol 2002*
• IRef Ophid Interaction: IL4R — JAK1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Madden et al., J Immunol 2002 : Binding of IL-4 by either the type 1 or 2 IL-4R, or of IL-13 by the type 2 IL-4R, initiates Jak dependent tyrosine phosphorylation of the IL-4Ralpha-chain and the transcription factor, STAT6
Moriggl et al., Eur J Biochem 1998 : The activation of both STAT6 and janus kinase 1 (JAK1) by the interleukin-4 receptor was completely abolished by disruption of the membrane-proximal ` box1 ' motif in the interleukin-4 receptor alpha chain