Gene interactions and pathways from curated databases and text-mining

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IL6 — UTP20

Text-mined interactions from Literome

Abbott et al., Mol Pharmacol 2000 : IL-6 mRNA induction by UTP is more rapid and transient then that caused by IL-1beta stimulation and is partially blocked by cyclosporin A or by expression of a trans-dominant NFAT inhibitor ... However, trans-dominant NFkappaB inhibitors strongly interfere with IL-6 mRNA induction both by IL-1beta and by UTP , which synergistically evoke IL-6 mRNA expression
Yoshida et al., Eur J Pharmacol 2006 : While a protein kinase C inhibitor ( GF109203X, 10 microM ) was without effect, an intracellular free Ca2+ chelator ( BAPTA-AM, 50 microM ) suppressed UTP mediated IL-6 induction
Kobayashi et al., J Pharmacol Sci 2006 (Calcium Signaling) : UTP causes interleukin (IL)-6 production via mRNA expression through P2Y(2)/P2Y(4) receptors in human HaCaT keratinocytes ... In the present study, we analyzed the mechanism of UTP induced IL-6 production in these cells ... PD98059, a MEK ( mitogen activated protein kinase kinase ) inhibitor, and BAPTA-AM [ O, O'-bis ( 2-aminophenyl ) ethyleneglycol-N, N,N ', N'-tetraacetic acid, tetraacetoxymethyl ester ], an intracellular Ca ( 2+ ) chelator, reduced UTP induced ERK phosphorylation and IL-6 mRNA expression ... 2-APB [ ( 2-aminoethoxy ) diphenylborane ], an inositol 1,4,5-trisphosphate ( IP ( 3 ) ) -receptor antagonist, inhibited UTP induced IL-6 mRNA expression ; and the action of A23187, a Ca ( 2+ ) ionophore, resembled the action of UTP ... In contrast, protein kinase C ( PKC ) downregulation and pertussis toxin did not affect UTP induced IL-6 mRNA expression, suggesting that PKC and G ( i ) are not involved in the UTP induced IL-6 production ... However, AG1478, an epidermal growth factor (EGF)-receptor inhibitor, partially decreased UTP induced ERK phosphorylation and IL-6 expression ... These results suggest that UTP induced IL-6 production is in part mediated via phosphorylation of ERK through G ( q/11 ) /IP ( 3 ) / [ Ca ( 2+ ) ] ( i ) and transactivation of the EGF receptor
Kobayashi et al., Eur J Pharmacol 2007 : Cooperation of calcineurin and ERK for UTP induced IL-6 production in HaCaT keratinocytes ... UTP causes IL-6 production in HaCaT keratinocytes, which is partially inhibited by PD98059, a mitogen activated protein kinase kinase ( MEK ) inhibitor, suggesting that a pathway other than the extracellular signal regulated kinase ( ERK ) pathway is involved in the production ... In the present study, we examined the involvement of calcineurin in the UTP induced interleukin (IL)-6 production in HaCaT keratinocytes ... FK506 and cyclosporine A, calcineurin inhibitors, partially inhibited UTP induced IL-6 mRNA expression and protein production ... In addition, combined application of FK506 and PD98059 synergistically inhibited the UTP induced IL-6 production ... These results suggest that ERK and calcineurin are cooperatively involved in UTP induced IL-6 production