Gene interactions and pathways from curated databases and text-mining

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CASP16 — IL8

Text-mined interactions from Literome

Dunican et al., Shock 2000 : To establish the effect of IL-8 or Gro-alpha on pro-apoptotic caspase activity, the cleavage of specific colorimetric substrates was assessed ... The effect of IL-8 and Gro-alpha does not depend on activation of the Fas, TNFR55, or R75 receptor pathways but involves suppression of caspase 3 activity
Choi et al., Mol Cell Biol 2002 (Astrocytoma...) : Tumor necrosis factor related apoptosis inducing ligand induces caspase dependent interleukin-8 expression and apoptosis in human astroglioma cells
Guo et al., Blood 2003 : In the present study we confirm that Fas signaling induces both phenotypic and functional maturation of murine DCs, and we demonstrate that phenotypic maturation is associated with phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2, activation of caspase-1 , and secretion of interleukin-beta ( IL-1beta )
Wang et al., Ann Thorac Surg 2005 (Reperfusion Injury) : Myocardial tissue was then assessed for products of p38 MAPK activation, expression of tumor necrosis factor, interleukin-1beta and interleukin-6, and activation of caspase-1, caspase-3 and caspase-11
Kerkeni et al., Mol Cell Biochem 2006 : Furthermore, our results showed that HcyT was much more efficient than Hcy in activating caspase-3 or in inducing IL-8 secretion
da Silva Correia et al., Cell Death Differ 2007 (Breast Neoplasms) : In contrast, several lines of evidence show that Nod1 dependent JNK activation and IL-8 production did not require the presence of caspase 8 but required activation of TAK1 as well as RIP2
Fudala et al., Am J Physiol Lung Cell Mol Physiol 2007 (Pneumonia...) : Activity of both caspase-3 and caspase-9 was also suppressed by anti-IL-8 : IL-8 complex containing samples
Shushanov et al., Bull Exp Biol Med 2010 : Insulin-like growth factor-1 and insulin inhibit caspase-3/7 activation initiated by interleukin-1ß in the rat eye retinal neurons
Kim et al., J Ethnopharmacol 2011 (Anaphylaxis...) : Additionally, IHT inhibited the production of interleukin (IL)-6, IL-8 , and TNF-a, as well as the activation of nuclear factor-?B and caspase-1 in PMACI stimulated HMC-1
Lin et al., International journal of biological sciences 2011 (Carcinoma...) : Adding recombinant IL-8 ( rIL-8 ) resulted in decreased caspase-3 activity in Lcn-2 treated cells, whereas the addition of IL-8 antibodies resulted in significantly increased caspase-3 activity and decreased cell migration
Bian et al., Invest Ophthalmol Vis Sci 2011 : Caspase-5 knockdown reduced caspase-1 protein expression and activation and inhibited TNF-a induced IL-8 and MCP-1
Liao et al., Inflamm Res 2013 : Lipopolysaccharide/adenosine triphosphate mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1 mediated interleukin-1ß secretion