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EGR2 — INS

Text-mined interactions from Literome

Keeton et al., Endocrinology 2003 (Carcinoma, Hepatocellular...) : Insulin regulated expression of Egr-1 and Krox20 : dependence on ERK1/2 and interaction with p38 and PI3-kinase pathways ... Krox20 regulation and expression have been primarily studied in neural cells and tissues, but little has been previously reported on the presence of Krox20 in cells of hepatic origin or its regulation by insulin ... In cells pretreated with a PI3-K inhibitor, there was no reduction in the effect of insulin on Egr-1 and Krox20 , but an increase in Egr-1 transcription ... The rapid induction of ERK1/2 phosphorylation was completely blocked by pretreatment with a MEK1 inhibitor and was associated with a nearly complete inhibition of insulin stimulated induction of both Egr-1and Krox20 , indicating this pathway is necessary for insulin 's effect on these genes
Gillian et al., J Biol Chem 2004 : In addition, Ddx20 repressed Egr2 mediated activation of the endogenous insulin-like growth factor 2 (IGF2) gene