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IRAK1 — IRF7

Pathways - manually collected, often from reviews:

• KEGG Toll-like receptor signaling pathway: IRAK1 → IRF7 (protein-protein, activation)
• KEGG Measles: IRAK1/IRAK4 → IRF7 (protein-protein, activation)
• Reactome Reaction: IRF7 → IRAK1 (indirect_complex) Kawai et al., Nat Immunol 2004, Honda et al., Proc Natl Acad Sci U S A 2004*, Uematsu et al., J Exp Med 2005, Ning et al., Mol Cell Biol 2008
• Reactome Reaction: IRF7 → IRAK1 (reaction) Marié et al., Mol Cell Biol 2000*, Kawai et al., Nat Immunol 2004, Honda et al., Proc Natl Acad Sci U S A 2004*, Uematsu et al., J Exp Med 2005, Ning et al., Mol Cell Biol 2008
• WikiPathways Regulation of toll-like receptor signaling pathway: IRAK1 → IRF7 (activation)
• WikiPathways Toll-like Receptor Signaling Pathway: IRAK1 → IRF7 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: IRAK1 — IRF7 (physical association, affinity chromatography technology) Uematsu et al., J Exp Med 2005
• IRef Biogrid Interaction: IRAK1 — IRF7 (direct interaction, enzymatic study) Uematsu et al., J Exp Med 2005
• IRef Biogrid Interaction: IRAK1 — IRF7 (direct interaction, fluorescent resonance energy transfer) Uematsu et al., J Exp Med 2005
• IRef Biogrid Interaction: IRAK1 — IRF7 (physical association, affinity chromatography technology) Li et al., Immunity 2011
• IRef Biogrid Interaction: IRAK1 — IRF7 (direct interaction, pull down) Li et al., Immunity 2011
• IRef Hprd Interaction: IRAK1 — IRF7 (in vivo) Uematsu et al., J Exp Med 2005
• IRef Innatedb Interaction: IRF7 — IRAK1 (unknown, -) Uematsu et al., J Exp Med 2005
• IRef Intact Interaction: Complex of 14 proteins (association, anti tag coimmunoprecipitation) Li et al., Immunity 2011
• IRef Intact Interaction: IRF7 — IRAK1 (physical association, anti tag coimmunoprecipitation) Li et al., Immunity 2011

Text-mined interactions from Literome

Schoenemeyer et al., J Biol Chem 2005 : We also demonstrate that MyD88, interleukin 1 receptor associated kinase 1, and tumor necrosis factor receptor associated factor 6 are required for the activation of IRF5 and IRF7 in the TLR7 signaling pathway
Bruni et al., J Immunol 2013 (Inflammation...) : Previous work indicated that IRAK1 negatively regulates TRIF mediated activation of IRF3 and IRF7