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IRAK1 — RELA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Vig et al., J Biol Chem 1999
:
However, it is currently unknown whether
mPLK/IRAK catalytic activity is
required for IL-1 dependent
NF-kappaB activation
Thomas et al., J Immunol 1999
(Hypersensitivity, Delayed...) :
Activation of
IRAK leads in turn to nuclear translocation of
NF-kappaB , which directs expression of innate and adaptive immune response genes
Guo et al., Immunopharmacology 2000
:
Antisense
IRAK-1 oligonucleotide
blocks activation of
NF-kappa B and AP-1 induced by IL-18
Vig et al., J Biol Chem 2001
:
These results lead us to propose a model in which SIMPL functions to
regulate NF-kappaB activity by linking
IRAK/mPLK to IKKbeta/alpha containing complexes
Li et al., Proc Natl Acad Sci U S A 2001
:
Mutant I1A cells, lacking IL-1 receptor associated kinase (IRAK) mRNA and protein, have been used to study the
involvement of
IRAK in
NFkappaB and c-Jun N-terminal kinase (JNK) activation
Maeda et al., J Biol Chem 2001
(Stomach Neoplasms) :
In conclusion, H. pylori induced
NF-kappaB activation in epithelial cells is dependent on cag PAI and contact but does not
involve CD14 and
IRAK , whereas in macrophage/monocytic cells it is independent of cag PAI or contact but involves CD14 and TLR4
Wald et al., Eur J Immunol 2001
:
Furthermore, the death domain, but not the kinase activity of
IRAK , is
necessary for
NFkappaB activation in response to IL-18
Bannerman et al., J Biol Chem 2002
:
Together, these data suggest that the proximal signaling molecules involved in LPS induced NF-kappa B activation have a requisite involvement in LPS induced apoptosis and that the pathways leading to
NF-kappa B activation and apoptosis diverge downstream of
IRAK-1
Chen et al., J Biol Chem 2002
:
CaMKKc and Akt overexpression decreases
IRAK1 mediated
NF-kappaB activity and its association with MyD88 in response to IL-1beta stimulation ... Furthermore, CaMKKc and Akt overexpression increases IRAK1 phosphorylation at Thr ( 100 ), and point mutation of this site abrogates the inhibitory effect of Akt on
IRAK1 mediated
NF-kappaB activation
Yanagisawa et al., Biochem J 2003
:
However,
IRAK-1-S overexpressed in 293T cells
induced constitutive activation of
nuclear factor-kappaB (NF-kappaB) and c-Jun N-terminal kinase (JNK) independent of stimulation by IL-1, as did IRAK-1-W
Yeo et al., J Biol Chem 2003
:
In contrast, overexpression of
DN-IRAK1 or DN-TRAF6 only partially
inhibited CpG DNA induced Cox-2 promoter activity and
NF-kappaB activation, indicating the presence of additional signaling modulators downstream of MyD88
Ferlito et al., J Endotoxin Res 2002
:
Neither PTx nor PP2 inhibited LPS induced activation of interleukin receptor activated kinase (
IRAK ) or
inhibited translocation of
NF-kappaB
Bin et al., J Biol Chem 2003
:
Moreover, TIRP mediated
NF-kappaB activation is
inhibited by dominant negative mutants of IRAK,
IRAK-2 , TRAF6, and IKKbeta
Lee et al., J Biol Chem 2003
:
Saturated fatty acid ( lauric acid ) -induced
NFkappaB activation was
inhibited by a dominant negative mutant of TLR4, MyD88,
IRAK-1 , TRAF6, or IkappaBalpha in macrophages ( RAW264.7 ) and 293T cells transfected with TLR4 and MD2 ... Saturated fatty acid ( lauric acid ) -induced
NFkappaB activation was
inhibited by a dominant negative mutant of TLR4, MyD88,
IRAK-1 , TRAF6, or IkappaBalpha in macrophages ( RAW264.7 ) and 293T cells transfected with TLR4 and MD2
Luftig et al., Proc Natl Acad Sci U S A 2003
:
Epstein-Barr virus latent membrane protein 1
activation of
NF-kappaB through
IRAK1 and TRAF6 ... These data extend a role for IKKalpha in IKKbeta regulation, identify an unusual IKKbeta dependent and IKKgamma independent NF-kappaB activation, and indicate that
IRAK1 and TRAF6 are
essential for LMP1 induced
NF-kappaB activation
Mamidipudi et al., J Biol Chem 2004
:
We have previously shown that the activity of the interleukin-1 (IL-1) receptor associated kinase (
IRAK ) is
required for nerve growth factor (NGF) induced activation of
NF-kappaB and cell survival ( ( 2002 ) J. Biol. Chem. 277, 28010-28018 ) ... Moreover, transfection of kinase-dead iota PKC blocked both NGF- and IL-1 induced
IRAK activation and the activity of
NF-kappaB
Opitz et al., J Biol Chem 2004
:
Additionally, dominant negative
interleukin-1 receptor associated kinase 2, tumor necrosis factor receptor associated factor 6, NF-kappaB inducing kinase, transforming growth factor-beta activated kinase binding protein 2, and transforming growth factor-beta activated kinase 1 also
inhibited Nod2 dependent
NF-kappaB activation
Chen et al., Biochem Biophys Res Commun 2004
:
Moreover, P6 induces MUC5AC transcription via
TLR2-MyD88-IRAK1-TRAF6-TAK1 dependent p38 MAPK-AP1 and
IKKbeta-IkappaBalpha-NF-kappaB signaling pathways
Rao et al., Mol Cell Biol 2005
(Inflammation) :
Overexpression of
IRAK1c suppressed
NF-kappaB activation and blocked IL-1beta induced IL-6 as well as lipopolysaccharide- and CpG induced tumor necrosis factor alpha production in multiple cellular systems
Song et al., Proc Natl Acad Sci U S A 2006
:
Because IRAK1 is upstream of TRAF6 in IL-1 activation of NF-kappaB, the potential
role of
IRAK1 in LMP1 mediated
NF-kappaB activation through TRAF6 and inhibitor of kappaB (IkappaB) kinase ( IKK ) was initially investigated
Qin et al., J Biol Chem 2006
:
The above results indicate that although TLR8 mediated
NF-kappaB and JNK activation are
IRAK dependent , they do not require IRAK modification and are TAK1 independent
Suzuki et al., Trends Immunol 2006
:
Although each system seems to possess distinct activation mechanisms,
interleukin-1 receptor associated kinase ( IRAK)-4 is
essential for
NF-kappaB activation in Toll-like receptor ( TLR ) and T-cell receptor ( TCR ) signaling pathways
Hartupee et al., J Biol Chem 2008
:
IRAK1 , which is recognized to function upstream of TRAF6, is
required for both mRNA stabilization and activation of
NFkappaB
Ahmad et al., Blood 2008
:
Altogether, these results unequivocally show that HSV-1 induces TLR2 dependent activation of IL-15 gene expression, which requires the recruitment of both MyD88 and TIRAP/Mal and the activation of
IRAK1 and TRAF6
leading to
NF-kappaB translocation to the nucleus
Dasu et al., Diabetes 2008
:
High glucose increased TLR expression, myeloid differentiation factor 88,
interleukin-1 receptor associated kinase-1 , and
nuclear factor-kappaB (NF-kappaB) p65 dependent
activation in THP-1 cells
Loiarro et al., J Biol Chem 2009
:
GFP-MyD88- ( 27-72 ) exerted its effect by titrating IRAK1 and suppressing
IRAK1 dependent
NF-kappaB activation
Merry et al., J Heart Lung Transplant 2010
(Lung Injury...) :
Lungs were assessed for vascular permeability, myeloperoxidase content, bronchoalveolar lavage inflammatory cell and cytokine/chemokine content, as well as nuclear translocation of
nuclear factor kappaB (NFkappaB) and activator protein-1 (AP-1), and
interleukin-1 receptor associated kinase-1 ( IRAK-1 ) and stress activated protein kinase ( SAPK )
activation
Cui et al., J Biol Chem 2010
(Alzheimer Disease...) :
Differential
regulation of
interleukin-1 receptor associated kinase-1 ( IRAK-1 ) and IRAK-2 by microRNA-146a and
NF-kappaB in stressed human astroglial cells and in Alzheimer disease