Gene interactions and pathways from curated databases and text-mining

◀ Back to FOXO1

FOXO1 — IRS1

Text-mined interactions from Literome

González-Rodríguez et al., Diabetes 2010 : The absence of PTP1B in the double-mutant mice restored hepatic IRS1 mediated phosphatidylinositol (PI) 3-kinase/Akt/Foxo1 signaling ... Moreover, resveratrol treatment of hyperglycemic IRS2 ( -/- ) mice decreased hepatic PTP1B mRNA and inhibited PTP1B activity, thereby restoring IRS1 mediated PI 3-kinase/Akt/Foxo1 signaling and peripheral insulin sensitivity
Battiprolu et al., J Clin Invest 2012 (Body Weight...) : Furthermore, we found that FoxO1 dependent downregulation of IRS1 resulted in blunted Akt signaling and insulin resistance