Guo et al., Mol Endocrinol 2006
:
By contrast, insulin stimulation of Irs1 ( -/- ) MEFs caused FoxO degradation, not only because Irs2 expression increased but also because Irs2 efficiently activated p110alpha -- > Akt cascade ... Inhibition of Irs2 degradation with rapamycin caused persistent FoxO degradation even during prolonged insulin stimulation
Shimano et al., J Mol Med (Berl) 2007
(Insulin Resistance...) :
Taken together, TFE3/Foxo1 and SREBP-1c reciprocally regulate IRS-2 expression and insulin sensitivity in the liver
Kamagate et al., Endocrinology 2010
:
Increased FoxO1 activity augments the expression of insulin receptor (IR) and IR substrate (IRS)2 , which in turn inhibits FoxO1 activity in response to reduced insulin action