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CA2 — ITIH4
Text-mined interactions from Literome
Medina et al., Eur J Neurosci 1999
(Ion Channel Gating) :
We report that in rat hippocampal neuronal cultures,
GP120 induces a dramatic and persistent increase in
[Ca2+ ] i which is prevented by drugs that either deplete ( caffeine, carbachol, thapsigargin ) or block ( dantrolene ) Ca2+ release from intracellular stores ... Our results show that the
GP120 induced rise in
[Ca2+ ] i originates from intracellular calcium stores, and suggest that intracellular stores of calcium may play a determinant role in the pathological actions of GP120
Holden et al., Neuroscience 1999
:
Role of Na+/H+ exchangers, excitatory amino acid receptors and voltage operated Ca2+ channels in human immunodeficiency virus type 1
gp120 mediated
increases in intracellular
Ca2+ in human neurons and astrocytes ... The N-methyl-D-aspartate receptor antagonists ( +/- ) -2-amino-5-phosphonopentanoic acid ( AP5 ), memantine and dizocilpine significantly ( P < 0.01 ) lowered
gp120 induced increases in [
Ca2+ ] i in neurons ... Drugs that block
gp120 induced changes in
[Ca2+ ] i in neurons and astrocytes may help in the treatment of HIV-1 dementia
Belmadani et al., Neuroscience 2001
(AIDS Dementia Complex...) :
Consistent with abrogation of excitotoxic pathways, fura-2 imaging showed selective deficits in
gp120 dependent intracellular
Ca2+ responses in ethanol pretreated slices
Minami et al., Neuropharmacology 2003
(Pain) :
Gp120 evoked allodynia in a dose dependent manner with the maximum effect at 1 pg/mouse, and
stimulated a rapid increase in intracellular free
Ca2+ concentration ([Ca2+]i) in the dorsal horn cells of the spinal cord ... The kappa-opioid agonist U-50,488 significantly enhanced the
gp120 stimulated increase in [
Ca2+ ] i in spinal slices prepared from EP3 ( -/- ) mice, and the simultaneous addition of U-50,488 with gp120 reproduced the gp120 induced allodynia in EP3 ( -/- ) mice
Lo et al., Brain Res 1992
:
Three patterns of [Ca2+ ] i increases were observed : in one pattern the [Ca2+ ] i rose rapidly and transiently as a single peak, in a second pattern
gp120 induced
[Ca2+ ] i oscillations that subsided when the protein was removed, and in a third pattern the oscillations continued long after washout of gp120
Lipton et al., Neuron 1991
:
Moreover, complete protection from
gp120 induced
[Ca2+ ] i increases and neurotoxicity is afforded by incubation with glutamate-pyruvate transaminase, which breaks down endogenous glutamate as verified by HPLC
Nath et al., Brain Res 1995
:
The peak levels of
gp120 induced increases in
[Ca2+ ] i were not affected by calcium channel blockers lanthanum and nicardipine, by glutamate receptor antagonists MK-801 and NBQX, or by removal of endogenous glutamate with glutamate dehydrogenase