Konforte et al., J Immunol 2006
:
Our study is the first to show the link between IL-21 induced JAK/STAT signaling, c-Myc regulation , and differentiation of human B cells
Lee et al., J Cell Biochem 2009
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JAK pathway induction of c-Myc critical to IL-5 stimulation of cell proliferation and inhibition of apoptosis
Li et al., PloS one 2012
(Hypereosinophilic Syndrome) :
Interestingly, JAK2 inhibition also reduced PI3K, Akt and NF-?B activity in a dose dependent manner, and suppressed expression levels of c-Myc and Survivin