Gene interactions and pathways from curated databases and text-mining

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CXCL2 — JUN

Text-mined interactions from Literome

Cinatl et al., Int J Mol Med 2005 (Colonic Neoplasms...) : High hydrocortisone concentrations ( > or =50 microg/ml ) completely prevented increased DNA binding activity of AP-1 and NF-kappaB and inhibited up-regulation of CXCL8 and CXCL10, but did not reduce chemokine expression to basal levels
D'Aversa et al., J Neurosci Res 2008 (AIDS Dementia Complex...) : Gel shift analyses demonstrated that NFkappaB and AP-1 , but not C/EBPbeta, mediate microglial CXCL8 production
Li et al., J Clin Endocrinol Metab 2011 (Inflammation...) : In IL-1ß- or TNF-a stimulated first trimester decidual cells, NF?B inhibitor suppressed production of all six chemokines ; JUN NH2-terminal kinase inhibitor inhibited secretion of CCL2, CCL4, and CCL5 ; and MAPK kinase and p38 inhibitor decreased production of CXCL8
Oh et al., J Immunol 2012 (Otitis Media) : ERK2 dependent activation of c-Jun is required for nontypeable Haemophilus influenzae induced CXCL2 upregulation in inner ear fibrocytes