Gene interactions and pathways from curated databases and text-mining

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JUN — PGF

Pathways - manually collected, often from reviews:

  • KEGG Pathways in cancer: JUN → FIGF/PGF/VEGFA/VEGFB/VEGFC (gene expression, expression)

Text-mined interactions from Literome

Tokuda et al., Prostaglandins Leukot Essent Fatty Acids 2004 (MAP Kinase Signaling System) : In the present study, we investigated the involvement of stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) , a member of the MAP kinase superfamily, in PGF2 ( alpha ) -induced HSP27 in MC3T3-E1 cells
Diaz et al., Domest Anim Endocrinol 2013 : At 10 h after PGF2a there was elevated FOSB mRNA in day-17 ( 771 % ) but not day-9 CL and no PGF2a induced change in FOS, JUN , JUND, and JUNB mRNA in day-9 or day-17 CL. Treatment with PGF2a increased mRNA for AP-1-responsive genes, CCL2 at 0.5 h ( 202 % ) and CCL2 and SERPINE1 at 10 h ( 719 % and 1,515 % ), only in day-17 CL ... However, PGF only induced JUN and JUND expression in CL with luteolytic capacity, a finding that may be key for understanding the acquisition of luteolytic capacity, given that JUN is the only AP-1 family member with strong N-terminal trans-activation activity