Gene interactions and pathways from curated databases and text-mining

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FOXO1 — KLF2

Text-mined interactions from Literome

Kerdiles et al., Nat Immunol 2009 : In naive T cells, Foxo1 controlled the expression of the adhesion molecule L-selectin, the chemokine receptor CCR7 and the transcription factor Klf2 , and its deletion was sufficient to alter lymphocyte trafficking ... Finally, growth factor withdrawal induced a Foxo1 dependent increase in Sell, Klf2 and Il7r expression
Lee et al., Cardiovasc Res 2013 (Diabetes Mellitus, Type 2...) : This study was designed to evaluate the reciprocal regulation of KLF2 by the forkhead transcription factor FOXO1 , and the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin, in hyperglycaemic conditions ... Adenoviral transfection of constitutively active FOXO1 suppressed KLF2 expression ... High-glucose induced, FOXO1 mediated KLF2 suppression was reversed by atorvastatin, suggesting that intensive statin treatment could be a therapeutic option in diabetic vascular dysfunction ... High-glucose induced, FOXO1 mediated KLF2 suppression was reversed by atorvastatin, suggesting that intensive statin treatment could be a therapeutic option in diabetic vascular dysfunction