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KLF2 — NOS3
Text-mined interactions from Literome
SenBanerjee et al., J Exp Med 2004
(Inflammation) :
Overexpression of
KLF2 in umbilical vein endothelial cells robustly
induced endothelial
nitric oxide synthase expression and total enzymatic activity
Lin et al., Circ Res 2005
(Thrombosis) :
Overexpression of
KLF2 strongly
induced thrombomodulin (TM) and
endothelial nitric oxide synthase (eNOS) expression and reduced plasminogen activator inhibitor-1 ( PAI-1 ) expression
Huddleson et al., J Biol Chem 2005
:
Finally, we have found that
KLF2 increases endothelial
nitric-oxide synthase expression in murine endothelial cultures, an effect that is also blocked by PI3K inhibition
Sen-Banerjee et al., Circulation 2005
:
Here we report that statin induced expression of
endothelial NO synthase (eNOS) and thrombomodulin is
KLF2 dependent ... Taken together, these observations indicate that statin dependent induction of
eNOS and thrombomodulin
requires KLF2 and thereby provides a novel molecular target for modulating endothelial function in vascular disease
van Thienen et al., Cardiovasc Res 2006
(Atherosclerosis...) :
We demonstrate that prolonged shear stress has a potential that is superior to that of statins to induce the
KLF2 dependent expression of
eNOS and TM, especially in the presence of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha)
Ali et al., J Biol Chem 2009
:
Mechanistically, synergy required Akt phosphorylation, activation of
Kruppel-like factor 2 , NF-E2 related factor-2 (Nrf2),
increased nitric-oxide synthase activity, and enhanced HO-1 mRNA stability
Boon et al., Eur Heart J 2011
(Coronary Artery Disease...) :
Lentiviral overexpression of
KLF2 increased human PAC numbers and endothelial
nitric oxide synthase expression by 60 % during in vitro culture
Chandra et al., Arterioscler Thromb Vasc Biol 2011
(Anoxia...) :
This was secondary to downregulation of endothelial nitric oxide synthase (eNOS), which was associated with reduced expression of
Kruppel-like factor 2 (KLF2) , a known
regulator of
eNOS expression