Gene interactions and pathways from curated databases and text-mining

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KLF6 — TP53

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Banck et al., FEBS Lett 2006 (Neoplasms) : KLF6 degradation occurred in the presence or absence of p53 , was associated with ubiquitination, mediated by the proteasome ( half-life 16min, unstimulated ), and independent of caspases and calpain
Tarocchi et al., Hepatology 2011 (Carcinoma, Hepatocellular...) : Whereas KLF6 overexpression in HCC cell lines and primary hepatocytes led to reduced MDM2 levels and increased p53 protein and transcriptional activity, reduction in KLF6 by small interfering RNA led to increased MDM2 and reduced p53