Yu et al., Clin Cancer Res 2007
(Leukemia...) :
In contrast, constitutively active MAPK or Akt attenuated LBH589 or LBH589 + AEE788 induced apoptosis
Edwards et al., Mol Cancer Ther 2007
(Lung Neoplasms) :
LBH589 resulted in increased acetylation of Hsp90 and reduced association of Hsp90 with EGFR, Akt , and STAT3 ... A 10-fold increase in LBH589 was necessary to observe durable depletion of EGFR and Akt in cells not harboring EGFR mutation