Gene interactions and pathways from curated databases and text-mining

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LPA — MMP17

Text-mined interactions from Literome

Fishman et al., Cancer Res 2001 (Neoplasm Invasiveness...) : In the current study, the effect of LPA on MMP expression and invasive activity was investigated
Zhao et al., J Biol Chem 2006 : Overexpression of dominant negative PKCdelta or pretreatment with a PKCdelta inhibitor ( rottlerin ) or Src kinase family inhibitor ( PP2 ) partially blocked LPA induced MMP activation, proHB-EGF shedding, and EGFR tyrosine phosphorylation ... Down-regulation of Lyn kinase, but not Src kinase, by specific small interfering RNA mitigated LPA induced MMP activation, proHB-EGF shedding, and EGFR phosphorylation
Wang et al., Gynecol Oncol 2011 (Neoplasm Invasiveness...) : Furthermore, MMP-1 and PAR1 were both significantly induced by LPA ( 20 µM ), and siRNA silencing of MMP-1 and PAR1 both significantly reduced LPA 's invasion promoting effect in DOV13 cells ( p < 0.05 )
Komachi et al., Cancer Sci 2012 (Ascites...) : Ki16198 inhibited LPA induced migration and invasion in several pancreatic cancer cells in vitro, which was associated with the inhibition of LPA induced MMP production