Chen et al., Exp Cell Res 2010
:
Inhibition of mitogen activated protein kinase kinase 1 ( MEK 1 ) either directly with PD98059 or with MEK 1 siRNA resulted in inhibition of EPO mediated suppression of EMT and Smad signal transduction in TGF-beta1 treated cells
Amatangelo et al., Carcinogenesis 2012
(Prostatic Neoplasms) :
Mechanistic studies revealed that in cells stably transfected with activated Ras, TGF-ß alone induced EMT and that a Ras-Raf-MEK1, but not MEK2 , signaling cascade is necessary and sufficient for Erk2 nuclear localization that works in concert with TGF-ß to promote EMT