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MAP2K7 — MAP3K1

Pathways - manually collected, often from reviews:

• KEGG Neurotrophin signaling pathway: MAP3K1 → MAP2K7 (protein-protein, activation)
• KEGG GnRH signaling pathway: MAP3K1 → MAP2K4/MAP2K7 (protein-protein, activation)
• Reactome Reaction: MAP3K1 → MAP2K7 (reaction) Kim et al., Cancer Res 2001*, Cuenda et al., Biochem J 1998*
• WikiPathways Structural Pathway of Interleukin 1 (IL-1): MAP3K1 → MAP2K7 (activation)
• WikiPathways Cardiac Hypertrophic Response: MAP3K1 → MAP2K4/MAP2K7 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: MAP2K7 — MAP3K1 Karandikar et al., J Biol Chem 2000*
• IRef Bind_translation Interaction: MAP2K7 — MAP3K1 (coimmunoprecipitation) Karandikar et al., J Biol Chem 2000*
• IRef Biogrid Interaction: MAP2K7 — MAP3K1 (physical association, affinity chromatography technology) Tu et al., J Biol Chem 2003*
• IRef Biogrid Interaction: MAP2K7 — MAP3K1 (direct interaction, pull down) Takekawa et al., Mol Cell 2005*
• IRef Intact Interaction: MAP2K7 — MAP3K1 (physical association, anti tag coimmunoprecipitation) Nakajima et al., EMBO J 2006*

Text-mined interactions from Literome

Tu et al., Cell Signal 2003 : They consist of a three-kinase module in which a mitogen activated protein kinase kinase kinase ( MAP3K ) activates a mitogen activated protein kinase kinase ( MAP2K ), which in turn activates MAPK
Huang et al., Biochem Biophys Res Commun 2003 : MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a mitogen activated protein kinase kinase ( MAP2K ), which in turn activates a mitogen activated protein kinase ( MAPK )