◀ Back to MMP1
MAP3K1 — MMP1
Text-mined interactions from Literome
Faour et al., J Biol Chem 2006
(Arthritis, Rheumatoid...) :
Role in suppression of c/EBP/NF-kappaB mediated
MEKK1 induced
MMP-1 expression ...
MEKK1 induced
MMP-1 promoter-driven luciferase activity was largely dependent on a c/EBPbeta-NF-kappaB-like enhancer site at -2008 to -1972 bp, as judged by deletion and point mutation analyses ... PGE ( 2 ), overexpression of p53wt with PGE ( 2 ), or p53S15E abolished the
MEKK1 induced
MMP-1 promoter luciferase activity
Hammaker et al., Arthritis Res Ther 2007
(Arthritis, Rheumatoid) :
Using either small interfering RNA ( siRNA ) knockdown or knockout fibroblast-like synoviocytes ( FLSs ),
MEKK1 , MEKK2, or MEKK3 deficiency ( either alone or in combination )
had no effect on IL-1beta stimulated phospho-JNK ( P-JNK ) induction or
MMP expression