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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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MAP3K1 — MMP1

Text-mined interactions from Literome

Faour et al., J Biol Chem 2006 (Arthritis, Rheumatoid...) : Role in suppression of c/EBP/NF-kappaB mediated MEKK1 induced MMP-1 expression ... MEKK1 induced MMP-1 promoter-driven luciferase activity was largely dependent on a c/EBPbeta-NF-kappaB-like enhancer site at -2008 to -1972 bp, as judged by deletion and point mutation analyses ... PGE ( 2 ), overexpression of p53wt with PGE ( 2 ), or p53S15E abolished the MEKK1 induced MMP-1 promoter luciferase activity
Hammaker et al., Arthritis Res Ther 2007 (Arthritis, Rheumatoid) : Using either small interfering RNA ( siRNA ) knockdown or knockout fibroblast-like synoviocytes ( FLSs ), MEKK1 , MEKK2, or MEKK3 deficiency ( either alone or in combination ) had no effect on IL-1beta stimulated phospho-JNK ( P-JNK ) induction or MMP expression