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MAP2K4 — MAP3K10

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAP2K4 — MAP3K10 (direct interaction, enzymatic study) Hirai et al., J Biol Chem 1997*
• IRef Hprd Interaction: MAP2K4 — MAP3K10 (in vitro) Hirai et al., J Biol Chem 1997*
• IRef Ophid Interaction: MAP2K4 — MAP3K10 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Tu et al., Cell Signal 2003 : They consist of a three-kinase module in which a mitogen activated protein kinase kinase kinase ( MAP3K ) activates a mitogen activated protein kinase kinase ( MAP2K ), which in turn activates MAPK
Huang et al., Biochem Biophys Res Commun 2003 : MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a mitogen activated protein kinase kinase ( MAP2K ), which in turn activates a mitogen activated protein kinase ( MAPK )
Hirai et al., J Biol Chem 1997 : MST/MLK2 , a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1 , an activator of c-Jun N-terminal kinase/stress activated protein kinase ... The activity of SEK1/MKK4/JNKK , a MAPK kinase class protein kinase designated as a direct activator of JNK/SAPK, is also induced by MUK/DLK/ZPK or MST/MLK2 overexpression ... Furthermore, recombinant MST/MLK2 produced in bacteria directly phosphorylates and activates SEK1/MKK4/JNKK in vitro, showing that MST/MLK2 acts like a MAPK kinase kinase
Cuenda et al., Biochem J 1998 : Here we demonstrate that MLK2 activates SAPK kinase-1 (SKK1)/MAPK kinase 4 ( MKK4 ) and SKK4/MKK7, the two known direct activators of SAPK1/JNK ( both in transfection studies and in vitro )