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LYN — MAPK1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kawauchi et al., Int J Hematol 2002
(Leukemia, Lymphocytic, Chronic, B-Cell...) :
In B-CLL cells, BCR cross linking neither induced activation nor
enhanced the activities of
Lyn , Syk, p21ras, JNK, p38 MAPK, or Akt kinases, whereas p38
MAPK and Akt were constitutively active
Tomkowicz et al., Blood 2006
(Acquired Immunodeficiency Syndrome...) :
Stimulation of human monocyte derived macrophages with either HIV-1 gp120 or MIP-1beta results in the CCR5 mediated activation of
Lyn and the concomitant Lyn dependent
activation of the mitogen activated protein ( MAP ) kinase
ERK-1/2
Jiang et al., J Exp Med 1998
:
However, BCR mediated p38 MAPK activation was abolished in Lyn/Syk double deficient cells, demonstrating that either
Lyn or Syk alone may be
sufficient to activate p38
MAPK
Hayashi et al., Nature 1999
:
As a
result of activation of
Lyn , the mitogen activated protein kinase (
MAPK ) signalling pathway is activated, and the expression of brain derived neurotrophic factor (BDNF) messenger RNA is increased in a Lyn-kinase dependent manner