Ling et al., Diabetes 2003
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Studies in beta-cell lines indicated that IL-1beta reduced expression of islet brain (IB)-1/JNK interacting protein (JIP)-1, a JNK scaffold protein with antiapoptotic action ... A similar increase in TNF-alpha + IFN-gamma induced apoptosis was produced by adenoviral expression of antisense IB1/JIP-1 and was not further enhanced by addition of IL-1beta, indicating that IL-1beta mediated suppression of IB1/JIP-1 in beta-cells increases their susceptibility to cytokine induced apoptosis
Blanco et al., PloS one 2008
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We report that in vivo, the activity of JIP1-JNK complexes is downregulated by VRK2 in response to interleukin-1beta