Gene interactions and pathways from curated databases and text-mining

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CDKN1A — MCL1

Text-mined interactions from Literome

Dasmahapatra et al., Clin Cancer Res 2007 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : These findings suggest that combined treatment with vorinostat and sorafenib synergistically induces apoptosis in CML cells through a process that involves Mcl-1 down-regulation and inhibition of p21 ( CIP1 ) induction
Wu et al., Exp Lung Res 2011 (Adenocarcinoma...) : Mechanisms underlying this shift are undefined ; however, the cell cycle inhibitor p21 delays the loss of antiapoptotic Mcl-1 and Bcl-X ( L ), and protects against hyperoxia ... Conditional overexpression of p21 selectively delayed the loss of Mcl-1 and Bcl-X ( L ), without affecting expression of the other members