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CDKN1A — MCL1
Text-mined interactions from Literome
Dasmahapatra et al., Clin Cancer Res 2007
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
These findings suggest that combined treatment with vorinostat and sorafenib synergistically induces apoptosis in CML cells through a process that involves
Mcl-1 down-regulation and
inhibition of
p21 ( CIP1 ) induction
Wu et al., Exp Lung Res 2011
(Adenocarcinoma...) :
Mechanisms underlying this shift are undefined ; however, the cell cycle inhibitor
p21 delays the loss of antiapoptotic
Mcl-1 and Bcl-X ( L ), and protects against hyperoxia ... Conditional overexpression of
p21 selectively
delayed the loss of
Mcl-1 and Bcl-X ( L ), without affecting expression of the other members