Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Kremerskothen et al., Neurosci Lett 2002 (Neuroblastoma) : Insulin induced expression of the activity regulated cytoskeleton associated gene ( ARC ) in human neuroblastoma cells requires p21(ras), mitogen activated protein kinase/extracellular regulated kinase and src tyrosine kinases but is protein kinase C-independent
Malabu et al., Peptides 1992 (Body Weight) : We tested the hypothesis that low plasma insulin levels stimulate ARC levels of NPY in fasted rats
Gopalakrishnan et al., Biochem Cell Biol 2006 (Diabetes Mellitus, Experimental) : In the vertebrae, TRAP activity was elevated as a result of diabetes, but this was prevented by insulin or estradiol
Schwartz et al., Endocrinology 1991 (Obesity) : Thus, insulin reduced the expression of mRNA for NPY specifically in the ARC
Newman et al., Endocrinology 1985 : Mediator generation was rapid, with a half-time of approximately 45 sec and was insulin dose dependent