Gene interactions and pathways from curated databases and text-mining

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CXCL2 — MIF

Text-mined interactions from Literome

Coleman et al., J Immunol 2008 (Carcinoma, Non-Small-Cell Lung...) : Because MIF has important autocrine effects on normal and transformed cells, we investigated whether autocrine MIF and its only known family member, D-dopachrome tautomerase (D-DT), promote the expression of proangiogenic factors CXCL8 and vascular endothelial growth factor in NSCLC cells ... CXCL8 transcriptional regulation by MIF and D-DT appears to involve a signaling pathway that includes the activation of JNK, c-jun phosphorylation, and subsequent AP-1 transcription factor activity ... Finally, we demonstrate that the cognate MIF receptor, CD74, is necessary for both MIF- and D-DT induced JNK activation and CXCL8 expression, suggesting its potential involvement in angiogenic growth factor expression
Lue et al., Cell Signal 2011 : In T cells, MIF mediated activation of the JNK pathway led to upregulated gene expression of the inflammatory chemokine CXCL8