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MMP1 — TLR4

Text-mined interactions from Literome

Voelcker et al., Exp Dermatol 2008 (Disease Progression...) : Together, our results suggest that sHA in melanoma might promote tumor invasiveness by inducing MMP- and cytokine-expression, in part in a TLR4 dependent manner, providing new insights into the relationship between cancer and innate immunity
West et al., J Cell Biol 2008 : Surprisingly, MMP inhibitors block TLR signaling induced podosome disassembly, although stimulated endocytosis is unaffected, which demonstrates that the two phenomena are not obligatorily coupled
Lee et al., Exp Dermatol 2010 : These findings demonstrate that the activation of TLR2, TLR3 or TLR5 induces the expression of MMP-1 and MMP-9 in human epidermal keratinocytes ... In addition, NF-kappaB or JNK mediated the MMP-1 expression induced by TLR2, TLR3 and TLR5, whereas NF-kappaB, JNK or p38 MAPK mediated the MMP-9 expression induced by TLR2, TLR3 and TLR5
Ta et al., Atherosclerosis 2010 : DPP-4 ( CD26 ) inhibitor alogliptin inhibits TLR4 mediated ERK activation and ERK dependent MMP-1 expression by U937 histiocytes ... Taken together, this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and ERK dependent MMP expression by U937 cells, suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling
Geraghty et al., J Biol Chem 2011 (Pulmonary Disease, Chronic Obstructive) : In vitro cell culture studies demonstrated that cigarette smoke induced MMP-1 was regulated by TLR4 via MyD88/IRAK1 ... Therefore, our data indicate that TLR4 signaling, through MyD88 and IRAK1, plays a predominant role in MMP-1 induction by cigarette smoke
Samuvel et al., Endocrinology 2011 (Obesity) : TLR4 activation and IL-6 mediated cross talk between adipocytes and mononuclear cells synergistically stimulate MMP-1 expression ... Furthermore, although it has been shown that Toll-like receptor 4 (TLR4), a receptor mediating innate immune response, plays an important role in the obesity associated inflammation and insulin resistance, the effect of TLR4 activation in coculture of adipocytes and monocytes on MMP production has not been investigated ... We found that TLR4 activation and the coculture had a synergistic effect on MMP-1 production
Hirabara et al., Biochem Biophys Res Commun 2013 : Hyaluronan inhibits TLR-4 dependent cathepsin K and matrix metalloproteinase 1 expression in human fibroblasts