◀ Back to TLR4
MMP1 — TLR4
Text-mined interactions from Literome
Voelcker et al., Exp Dermatol 2008
(Disease Progression...) :
Together, our results suggest that sHA in melanoma might promote tumor invasiveness by inducing
MMP- and cytokine-expression, in part in a
TLR4 dependent manner, providing new insights into the relationship between cancer and innate immunity
West et al., J Cell Biol 2008
:
Surprisingly,
MMP inhibitors
block TLR signaling induced podosome disassembly, although stimulated endocytosis is unaffected, which demonstrates that the two phenomena are not obligatorily coupled
Lee et al., Exp Dermatol 2010
:
These findings demonstrate that the activation of TLR2,
TLR3 or TLR5
induces the expression of
MMP-1 and MMP-9 in human epidermal keratinocytes ... In addition, NF-kappaB or JNK mediated the
MMP-1 expression
induced by TLR2,
TLR3 and TLR5, whereas NF-kappaB, JNK or p38 MAPK mediated the MMP-9 expression induced by TLR2, TLR3 and TLR5
Ta et al., Atherosclerosis 2010
:
DPP-4 ( CD26 ) inhibitor alogliptin inhibits
TLR4 mediated ERK activation and ERK dependent
MMP-1 expression by U937 histiocytes ... Taken together, this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed
TLR4 mediated ERK activation and ERK dependent
MMP expression by U937 cells, suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling
Geraghty et al., J Biol Chem 2011
(Pulmonary Disease, Chronic Obstructive) :
In vitro cell culture studies demonstrated that cigarette smoke induced
MMP-1 was
regulated by
TLR4 via MyD88/IRAK1 ... Therefore, our data indicate that
TLR4 signaling, through MyD88 and IRAK1,
plays a predominant role in
MMP-1 induction by cigarette smoke
Samuvel et al., Endocrinology 2011
(Obesity) :
TLR4 activation and IL-6 mediated cross talk between adipocytes and mononuclear cells synergistically
stimulate MMP-1 expression ... Furthermore, although it has been shown that Toll-like receptor 4 (TLR4), a receptor mediating innate immune response, plays an important role in the obesity associated inflammation and insulin resistance, the
effect of
TLR4 activation in coculture of adipocytes and monocytes on
MMP production has not been investigated ... We found that
TLR4 activation and the coculture
had a synergistic effect on
MMP-1 production
Hirabara et al., Biochem Biophys Res Commun 2013
:
Hyaluronan inhibits
TLR-4 dependent cathepsin K and
matrix metalloproteinase 1 expression in human fibroblasts