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MMP13 — RELA

Text-mined interactions from Literome

Mengshol et al., Arthritis Rheum 2000 (MAP Kinase Signaling System) : We found that IL-1 induction of MMP-13 requires p38 activity, c-Jun N-terminal kinase (JNK) activity and NF-kappaB translocation ... These results suggest that both NF-kappaB and activator protein 1 transcription factors are necessary for IL-1 induction of MMP-13 ... In chondrosarcoma cells, MMP-1 induction depends on p38 and MEK ( an MAPK kinase of the extracellular signal regulated kinase pathway ) and does not require JNK or NF-kappaB ... These studies demonstrate, for the first time, that p38, JNK, and NF-kappaB are required for IL-1 induction of MMP-13
Sun et al., Frontiers in bioscience : a journal and virtual library 2002 (Arthritis, Rheumatoid) : The results support a stimulatory role of NF-kappa B in transcriptional regulation of MMP-1 and MMP-13
Shukla et al., Neoplasia (New York, N.Y.) 2004 (Adenocarcinoma...) : The nuclear levels of NF-kappaB/p65 correlated with concurrent increase in cytosolic levels of IkappaBalpha along with NF-kappaB dependent expression of Bcl2, cyclin D1, MMP-9 , and VEGF
Dai et al., Ann Rheum Dis 2005 (Arthritis...) : In chondrocytes responding to IL18, IL18 ( 1-100 ng/ml ) slightly increased the production of MMP-1, MMP-3 , and MMP-13, which was blocked by NF-kappaB inhibitor and p38 mitogen activated protein kinase inhibitor ... In chondrocytes responding to IL18, IL18 ( 1-100 ng/ml ) slightly increased the production of MMP-1, MMP-3, and MMP-13 , which was blocked by NF-kappaB inhibitor and p38 mitogen activated protein kinase inhibitor
Yoshida et al., Respirology 2006 (Pulmonary Emphysema) : A specific inhibitor of NF-kappaB reduced MMP production by alveolar macrophages from SP-D-/- mice
Fan et al., Rheumatol Int 2006 : Role of mitogen activated protein kinases and NFkappaB on IL-1beta induced effects on collagen type II, MMP-1 and 13 mRNA expression in normal articular human chondrocytes ... Inhibitors of ERK and NFkappaB could significantly block the induction of MMP-1 and -13 ( p < 0.05 ) and the repression of collagen type II ( p < 0.01 )
Popov et al., J Biol Chem 2006 (Liver Cirrhosis...) : p38 mitogen activated protein kinase ( p38 MAPK ) and nuclear factor kappaB(NFkappaB) pathways were activated by HAL, and specific inhibitors of p38 MAPK and NFkappaB dose dependently inhibited MMP-13 induction
Séguin et al., Matrix Biol 2006 (Disease Models, Animal...) : We demonstrate that in nucleus pulposus cells, the p38 and JNK pathways regulate induction of MMP-1 and -3 ; p38, JNK, and NF-kappaB regulate the induction of MMP-13 ; and ERK regulates the up-regulation of MT1-MMP mRNA in response to TNFalpha
Bachmeier et al., Cell Physiol Biochem 2007 (Breast Neoplasms...) : 68 % of Curcumin treated but only 17 % of untreated animals showed no or very few lung metastases, most likely as a consequence of down-regulation of NFkappa B/AP-1 dependent MMP expression and direct apoptotic effects on circulating tumor cells but not on established metastases
Yoon et al., Osteoarthritis Cartilage 2008 (Chondrosarcoma) : TNF-alpha induced MMP-13 expression was not suppressed by extracellular signal regulated kinase ( ERK ) inhibitors ( PD98059 and U0126 ) or a c-jun terminal kinase ( JNK ) inhibitor ( SP600125 ), but was inhibited by inhibitors of p38 kinase ( SB203580 ) and NF-kappaB ( SN-50 peptide ) and dnIKKalpha and dnIKKbeta
Bogatkevich et al., Arthritis Rheum 2007 (MAP Kinase Signaling System...) : Inhibition of MMP activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity, but significantly restored HGF inhibited collagen and CTGF accumulation
Alvarez-Soria et al., Rheumatology (Oxford) 2008 (Osteoarthritis, Knee) : The effects of diacerein, celecoxib, diclofenac, meloxicam and indomethacin on prostaglandin ( PG ) E2 production, cyclo-oxygenase-2 (COX-2) protein expression, nitrite levels, presence of MMP-1 and -13 , and activation of nuclear factor-kappaB (NF-kappaB) were studied on stimulated OA synoviocytes and chondrocytes
Wehling et al., Arthritis Rheum 2009 : Matrix metalloproteinase 13 was induced by IL-1beta in a NF-kappaB dependent manner
Castier et al., Antioxid Redox Signal 2009 : Hence, induction of NF-kappaB by shear stress contributes to MMP induction and allows long-term flow induced vascular enlargement
Konda et al., Journal of inflammation (London, England) 2009 : In addition, RIAA inhibited NF-kappaB mediated inflammatory markers in various cell models, including nitric oxide in LPS stimulated RAW 264.7 cells, RANKL mediated TRAP activity in transformed osteoclasts, and TNF-alpha/IL-1beta mediated MMP-13 expression in SW1353 human chondrosarcoma cells
Moon et al., Int Immunopharmacol 2010 (Arthritis, Experimental...) : Additionally, by altering nuclear factor (NF)-kappaB transcription activity in FLSs, curcumin inhibited PGE ( 2 ) production, COX-2 expression, and MMP secretion
Martinez-Orozco et al., Eur J Cell Biol 2010 (Neoplasm Invasiveness) : We demonstrate here that AA promotes an increase in vimentin and N-cadherin expression, MMP-9 secretion, a decrease in E-cadherin junctional levels, and the activation of FAK, Src and NF-kappaB in MCF10A cells
Catanzaro et al., J Biol Regul Homeost Agents 2012 : Western immunoblotting was used to analyze the MMP-13 production in the culture medium and the activation of NF-kB