Gene interactions and pathways from curated databases and text-mining

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MMP8 — SMC4

Text-mined interactions from Literome

Borges et al., Histopathology 2010 (Aortic Aneurysm, Thoracic) : Because the pericellular fibrinolytic system activation is able to degrade adhesive proteins, activate matrix metalloproteinase ( MMP ) , induce SMC disappearance and increase the bioavailability of TGF-ß, the aim was to investigate the plasminergic system in TAA
Jones et al., J Cell Biol 1997 : We show that a matrix metalloproteinase ( MMP ) inhibitor ( GM6001 ) suppresses SMC TN-C expression on native collagen, whereas denatured collagen promotes TN-C expression in a beta 3 integrin- dependent manner, independent of MMPs. Floating type I collagen gel also suppresses SMC MMP activity and TN-C protein synthesis and induces apoptosis, in the presence of EGF
Wang et al., J Vasc Res 1998 : Of particular interest is that expression of a 72-kD MMP ( MMP-2 ) is elevated in neointima, and inhibition of this MMP results in reduced SMC migration and proliferation, suggesting a role for MMP-2 in neointimal development