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FOXO1 — MTTP
Text-mined interactions from Literome
Sparks et al., J Clin Invest 2008
(Diabetes Mellitus, Type 2...) :
They demonstrate that MTP is a target of the transcription factor FoxO1 and that excessive VLDL production associated with insulin resistance is caused by the inability of insulin to regulate
FoxO1 transcriptional
activation of
MTP
Kamagate et al., J Clin Invest 2008
:
In HepG2 cells,
MTP expression was
induced by
FoxO1 and inhibited by exposure to insulin ... This effect correlated with the ability of
FoxO1 to bind and
stimulate MTP promoter activity