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IL9 — MUC4

Text-mined interactions from Literome

Longphre et al., J Clin Invest 1999 (Asthma) : Allergen induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells ... Furthermore, recombinant IL-9 , but not IL-5 or IL-13, stimulated mucin synthesis
Damera et al., Biosci Rep 2006 (Adenocarcinoma, Bronchiolo-Alveolar...) : In this study, we investigated the possible role of interleukin-9 (IL-9) , a Th2 cytokine, on MUC4 expression using a lung cancer cell line, NCI-H650 ... IL-9 also increased MUC4 glycoprotein expression as determined by Western blots using a monoclonal antibody specific for a non-tandem repeat region on ASGP-2 region of MUC4 ... Furthermore, a JAK3-selective inhibitor 4- ( 4'-hydroxyphenyl ) amino-6, 7-dimethoxyquinazoline ( WHI-P131 ), substantially reduced IL-9 induced MUC4 mRNA expression in a dose dependent fashion
Hauber et al., Laryngoscope 2008 (Hypersensitivity...) : IL-4, IL-9 , and IL-13 significantly increased epithelial mucin expression ( P < .05 ). Dexamethasone reduced Th2 type cytokine induced mucin expression in a dose dependent manner being statistically significant at concentrations > or=4.0 micromol/L ( IL-4 ) and > or=40.0 micromol/L ( IL-9 and IL-13 ) ( P < .05 ). ACC had no significant effect on IL-4 and IL-13 induced mucin expression, whereas IL-9 induced mucin expression was significantly decreased at concentrations > or=3.0 mmol/L ( P < .05 ). NFA and MSI-2216 decreased Th2 type cytokine induced mucin expression in a dose dependent manner. This effect was statistically significant at concentrations > or=100 micromol/L ( NFA ) and > or=50 micromol/L ( MSI-2216 ) ( P < .05 )
Lee et al., J Parasitol 2010 : We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and MUC expression is regulated by interferon (IFN)-gamma, interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen