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FOXO1 — MYLIP
Text-mined interactions from Literome
Guttilla et al., J Biol Chem 2009
(Breast Neoplasms) :
Coordinate
regulation of
FOXO1 by
miR-27a , miR-96, and miR-182 in breast cancer cells
Myatt et al., Cancer Res 2010
(Endometrial Neoplasms) :
Expression of
miR-9 , miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was
sufficient to significantly reduce the abundance of
FOXO1 ... Moreover,
induction of
FOXO1 in Ishikawa cells by
miR inhibitors was accompanied by G1 cell cycle arrest and cell death, and was attenuated by the small interfering RNA mediated downregulation of FOXO1 expression
Small et al., Proc Natl Acad Sci U S A 2010
:
Accordingly, PTEN and
Foxo1a protein levels are
reduced by
miR-486 overexpression, which, in turn, enhances PI3K/Akt signaling ... Conversely, inhibition of
miR-486 expression
enhances the expression of PTEN and
Foxo1a and dampens signaling through the PI3K/Akt signaling pathway