Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Kapinas et al., J Cell Biochem 2009 : These data suggest that canonical Wnt signaling, which is increased during osteoblastic differentiation, induces expression of miR-29
Kapinas et al., J Biol Chem 2010 : Specifically, canonical Wnt signaling induces miR-29a transcription
Zhang et al., J Bone Miner Res 2011 : In conclusion, miR-335-5p activates Wnt signaling and promotes osteogenic differentiation by downregulating DKK1
Zhou et al., Oncogene 2012 (Neoplasm Invasiveness...) : Mechanistically, three TCF/LEF1 binding elements (TBEs) were identified in the promoter region and shown to be required for Wnt dependent activation of miR-371-373
Strillacci et al., J Pathol 2013 (Adenocarcinoma...) : Loss of miR-101 expression promotes Wnt/ß-catenin signalling pathway activation and malignancy in colon cancer cells
Hassan et al., J Biol Chem 2012 (Mammary Neoplasms, Animal...) : In turn, miR-218 expression is up-regulated in response to stimulated Wnt signaling and functionally drives Wnt related transcription and osteoblast differentiation, thereby creating a positive feedback loop ... Furthermore, in metastatic breast cancer cells but not in normal mammary epithelial cells, miR-218 enhances Wnt activity and abnormal expression of osteoblastic genes ( osteomimicry ) that contribute to homing and growth of cells metastatic to bone
Hu et al., Mol Med Report 2013 : The adenomatous polyposis coli (APC) gene was a direct target of miR-142-3p, whereby miR-142-3p promoted Wnt signaling through inhibition of APC, leading to accumulation and nuclear translocation of ß-catenin
Zhang et al., J Clin Endocrinol Metab 2013 (Carcinoma...) : We have searched for miR-155 targets and identified the hypothesis that miR-155 could promote tumor growth of PTC by targeted regulation of adenomatous polyposis coli (APC) expression and activating the Wnt/ß-catenin signaling ... By targeting APC, miR-155 efficiently regulates the Wnt/ß-catenin signaling