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FOXO1 — MYOG
Text-mined interactions from Literome
Wang et al., Int J Oncol 2005
(Cell Transformation, Neoplastic...) :
In this study, we have investigated the
effects of
PAX3-FKHR and IGF-II on the expression of muscle regulatory factors ( myf5, MyoD and
myogenin ), and platelet derived growth factor-B ( PDGF-B ) and vascular endothelial growth factor ( VEGF ) in mouse C2C12 myoblasts in vitro ... Western blotting showed that
PAX3-FKHR and IGF-II
blocked the expression of
myogenin and MyoD respectively
Zhang et al., Oncogene 2007
:
We demonstrate that
PAX3-FKHR could
induce myogenin expression in undifferentiated myoblasts by a MyoD independent pathway, and that PAX3-FKHR is directly involved in myogenin expression in aRMS cells
Graf Finckenstein et al., Oncogene 2008
(Rhabdomyosarcoma, Alveolar) :
We show that while
PAX3-FKHR activates the expression of endogenous MyoD and
myogenin proteins in transduced NIH3T3 fibroblasts, it inhibits them from terminally differentiating as shown by low myogenin and myosin heavy chain expression, and lack of myotube formation
Calhabeu et al., Oncogene 2013
(Rhabdomyosarcoma, Alveolar) :
PAX3/FOXO1A or
PAX7/FOXO1A inhibited
myogenin expression and prevented terminal differentiation in murine satellite cells : the same effect as dominant negative ( DN ) Pax3 or Pax7 constructs ... The transcription of MyoD-target genes
myogenin and muscle creatine kinase were
suppressed by
PAX3/FOXO1A or PAX7/FOXO1A in C2C12 myogenic cells again as seen with Pax3/7DN