Junge et al., Cell 2009
:
Overexpressed TSPAN12 associates with the Norrin-receptor complex and significantly increases Norrin/beta-catenin but not Wnt/beta-catenin signaling, whereas Tspan12 siRNA abolishes transcriptional responses to Norrin but not Wnt3A in retinal endothelial cells
Seitz et al., J Neurosci 2010
:
The effects of Norrin involve activation of Wnt/beta-catenin signaling and subsequent induction of neurotrophic growth factors in Müller cells
Ohlmann et al., Prog Retin Eye Res 2012
(Glaucoma...) :
The neuroprotective effects of Norrin similarly involve an activation of Wnt/ß-catenin signaling and the subsequent induction of neuroprotective growth factor synthesis in Müller cells, such as that of fibroblast growth factor-2 (FGF2) or ciliary neurotrophic factor (CNTF)
Braunger et al., Neurobiol Dis 2013
:
Constitutive overexpression of Norrin activates Wnt/ß-catenin and endothelin-2 signaling to protect photoreceptors from light damage