Gene interactions and pathways from curated databases and text-mining

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JAK1 — NFKB1

Text-mined interactions from Literome

Kanda et al., Endocrinology 2007 (MAP Kinase Signaling System...) : Inhibitors of Janus kinase ( JAK ) , p38 MAPK, and MAPK/ERK kinase (MEK) suppressed prolactin- plus IFN-gamma induced CXCL9, CXCL10, and CXCL11 production and NF-kappaB , STAT1, and IRF-1 activities
Li et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis...) : JAK1/TYK2 leads to STAT3 activation, Akt dependent NF-kappaB activation, and phosphorylation of extracellular signal regulated kinase 1/2 and mitogen activated kinase p38
Hu et al., J Leukoc Biol 2007 : Similarly, basal ITAM signaling augments IFN signaling and function of receptor activator of NF-kappaB , but extensive ITAM activation inhibits Jak-STAT signaling
Huang et al., J Immunol 2007 : Requirement for both JAK mediated PI3K signaling and ACT1/TRAF6/TAK1 dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells
Qi et al., J Cell Physiol 2009 : IFN-gamma potentiates TNF-alpha induced CXCL10 production in THP-1 cells by increasing the activation of STAT1 and NF-kappaB through JAK1 and JAK2