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JAK1 — NFKB1
Text-mined interactions from Literome
Kanda et al., Endocrinology 2007
(MAP Kinase Signaling System...) :
Inhibitors of
Janus kinase ( JAK ) , p38 MAPK, and MAPK/ERK kinase (MEK)
suppressed prolactin- plus IFN-gamma induced CXCL9, CXCL10, and CXCL11 production and
NF-kappaB , STAT1, and IRF-1 activities
Li et al., Arterioscler Thromb Vasc Biol 2007
(Atherosclerosis...) :
JAK1/TYK2 leads to STAT3 activation, Akt dependent
NF-kappaB activation, and phosphorylation of extracellular signal regulated kinase 1/2 and mitogen activated kinase p38
Hu et al., J Leukoc Biol 2007
:
Similarly, basal ITAM signaling augments IFN signaling and function of receptor activator of
NF-kappaB , but extensive ITAM activation
inhibits Jak-STAT signaling
Huang et al., J Immunol 2007
:
Requirement for both
JAK mediated PI3K signaling and ACT1/TRAF6/TAK1 dependent
NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells
Qi et al., J Cell Physiol 2009
:
IFN-gamma potentiates TNF-alpha induced CXCL10 production in THP-1 cells by increasing the
activation of STAT1 and
NF-kappaB through
JAK1 and JAK2