Gene interactions and pathways from curated databases and text-mining

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NFKBIA — TLR9

Text-mined interactions from Literome

Mueller et al., J Immunol 2006 : TLR4/MD-2 mediated LPS uptake and TLR ligand induced I-kappaBalpha phosphorylation and IL-8 secretion were significantly diminished in Th2 cytokine primed IECs
Qin et al., J Biol Chem 2006 : On the other hand, TLR8 mediated IkappaBalpha phosphorylation, NF-kappaB, and JNK activation are completely abolished in MEKK3 ( -/- ) MEFs, whereas IL-1 mediated signaling was only moderately reduced in these deficient MEFs as compared with wild-type cells
Polumuri et al., J Immunol 2007 : Although TLR induced IkappaBalpha degradation was not affected by FcgammaR ligation, IkappaBalpha accumulated in the nuclei of cells treated with LPS and FcgammaR ligation for 4 h, and was blocked by PI3K inhibitors
Henning et al., J Immunol 2008 : SP-A decreases the phosphorylation of IkappaBalpha , a key regulator of NF-kappaB activity, and nuclear translocation of p65 which result in diminished TNF-alpha secretion in response to TLR ligands