Pallai et al., Gene 2010
(Liver Neoplasms...) :
The CCAAT box binding transcription factor, nuclear factor-Y (NF-Y) regulates transcription of human aldo-keto reductase 1C1 (AKR1C1) gene ... Site directed mutagenesis studies indicated that the transcription factor binding sites for NF-Y/CEBP were involved in controlling the basal transcription of AKR1C1 in all the cancer cells studied ... These results indicate that the NF-Y regulates the basal transcription of AKR1C1 in human ovarian, lung and liver carcinoma cells and the cisplatin induced transcription in human ovarian carcinoma cells
Li et al., Hepatitis monthly 2013
:
Site directed mutagenesis studies suggested that nuclear factor-Y (NF-Y) plays an important role in this HBx induced AKR1C1 activation