Gene interactions and pathways from curated databases and text-mining

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NOS2 — TNFSF11

Text-mined interactions from Literome

Takada et al., Blood 2004 : Nitric oxide ( NO ) production and expression of inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2) induced by RANKL was also maximally induced in double knock-out cells
Gyurko et al., Bone 2005 (Alveolar Bone Loss...) : Gene expression studies showed that iNOS expression is induced by M-CSF and RANKL in WT bone marrow cultures, while no iNOS transcript was detected in iNOS KO
Park et al., Exp Mol Med 2005 : In addition, RANKL increased the expression of TNFalpha, MCP-1, and IL-6 but not of IL-10, IL-12, IFN-gamma, and iNOS
Zheng et al., J Biol Chem 2006 (Bone Resorption) : RANKL stimulates inducible nitric-oxide synthase expression and nitric oxide production in developing osteoclasts ... Surprisingly, iNOS expression and NO release were also triggered by RANKL ... IFN-beta was induced by RANKL and stimulated iNOS expression and NO release, and a neutralizing antibody to IFN-beta inhibited iNOS/NO elevation in response to RANKL, thereby enhancing osteoclast formation
Zheng et al., Biochem Pharmacol 2013 (Bone Resorption) : Coumermycin A1 also abrogated RANKL induced expression of interleukin-1ß, tumor necrosis factor-a, and inducible nitric oxide synthase in mouse BMMs. Consistent with the in vitro anti-osteoclastogenic effect, the aminocoumarin suppressed lipopolysaccharide induced osteoclast formation and bone loss in in vivo mouse experiments