◀ Back to TNFSF11
NOS2 — TNFSF11
Text-mined interactions from Literome
Takada et al., Blood 2004
:
Nitric oxide ( NO ) production and expression of
inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2)
induced by
RANKL was also maximally induced in double knock-out cells
Gyurko et al., Bone 2005
(Alveolar Bone Loss...) :
Gene expression studies showed that
iNOS expression is
induced by M-CSF and
RANKL in WT bone marrow cultures, while no iNOS transcript was detected in iNOS KO
Park et al., Exp Mol Med 2005
:
In addition,
RANKL increased the expression of TNFalpha, MCP-1, and IL-6 but not of IL-10, IL-12, IFN-gamma, and
iNOS
Zheng et al., J Biol Chem 2006
(Bone Resorption) :
RANKL stimulates inducible
nitric-oxide synthase expression and nitric oxide production in developing osteoclasts ... Surprisingly,
iNOS expression and NO release were also
triggered by
RANKL ... IFN-beta was induced by
RANKL and
stimulated iNOS expression and NO release, and a neutralizing antibody to IFN-beta inhibited iNOS/NO elevation in response to RANKL, thereby enhancing osteoclast formation
Zheng et al., Biochem Pharmacol 2013
(Bone Resorption) :
Coumermycin A1 also abrogated
RANKL induced expression of interleukin-1ß, tumor necrosis factor-a, and inducible
nitric oxide synthase in mouse BMMs. Consistent with the in vitro anti-osteoclastogenic effect, the aminocoumarin suppressed lipopolysaccharide induced osteoclast formation and bone loss in in vivo mouse experiments