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IL4 — NOTCH3

Text-mined interactions from Literome

Okamoto et al., J Immunol 2009 (Bronchial Hyperreactivity...) : These data identify the essential role of the interactions between Notch on CD4 ( + ) T cells and Jagged1 on APCs in the initiation of IL-4 production and Th2 differentiation for the development of AHR and allergic airway inflammation
Watarai et al., Blood 2010 : Interestingly, in the presence of Notch signals, NKT-ES cells differentiated only to thymic CD44 ( lo ) CD24 ( hi ) NKT cells producing mainly interleukin-4 (IL-4) , whereas NKT cells resembling CD44 ( hi ) CD24 ( lo ) liver NKT cells producing mainly interferon gamma (IFN-gamma) and exhibiting strong adjuvant activity in vivo were developed in the switch culture starting at day 14 in the absence of Notch