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NOTCH3 — SMAD3

Text-mined interactions from Literome

Kennard et al., J Biol Chem 2008 : The repression of Notch3 was mediated by SMAD activity and p38 mitogen activated protein ( MAP ) kinase, whereas analysis of the Hes1 promoter revealed direct activation by Smad2 but not Smad3
Fu et al., J Biol Chem 2009 : In contrast, Notch increases SMAD3 mRNA expression and protein half-life and regulates the expression of TGFbeta/Smad3 target genes in a gene-specific manner ... Inhibition of Notch in the cardiac cushion of mouse embryonic hearts reduces Smad3 expression ... This is the first evidence that Notch activation affects R-Smad expression and that cooperative induction of histone acetylation at specific promoters underlies the selective synergy between Notch and TGFbeta signaling pathways