Gene interactions and pathways from curated databases and text-mining

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NFKB1 — ODC1

Text-mined interactions from Literome

Tantini et al., FEBS Lett 2002 : Here we show an involvement of nuclear factor-kappaB (NF-kappaB) in the induction of nitric oxide synthase (NOS) and ornithine decarboxylase (ODC) , the key enzyme in polyamine biosynthesis
Tacchini et al., Carcinogenesis 2004 (Breast Neoplasms...) : Hepatocyte growth factor activated NF-kappaB regulates HIF-1 activity and ODC expression, implicated in survival, differently in different carcinoma cell lines
Chung et al., Carcinogenesis 2007 (Acute Disease...) : When mouse skin was treated after TPA induced production of papillomas, xanthorrhizol remarkably suppressed the expression of ODC , iNOS and COX-2 and inhibited the activation of NF-kappaB ... Taken together, the present study demonstrates that xanthorrhizol not only delays or inhibits tumor formation, but also reverses the carcinogenic process at pre-malignant stages by reducing the protein levels of ODC , iNOS and COX-2 regulated by the NF-kappaB , mitogen activated protein kinases and/or Akt
Liao et al., Leuk Res 2008 : Meanwhile conventional expression of ODC represses tumor necrosis factor-alpha (TNF-alpha) expression and nuclear factor-kappaB (NF-kappaB) activation as well as MMP-9 enzyme activity ... Furthermore, ODC could directly inhibit and attenuate NF-kappaB DNA binding and transcriptional activation