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OSM — TIMP1

Text-mined interactions from Literome

Varghese et al., Am J Physiol 1999 : LIF and OSM modestly stimulated the expression of TIMP-1 but did not alter the expression of TIMP-2 and -3 ... In conclusion, LIF and OSM stimulate collagenase-3 and TIMP-1 expression in osteoblasts, and these effects may be involved in mediating the bone remodeling actions of these cytokines
Kerr et al., J Interferon Cytokine Res 1999 : Mouse oncostatin M ( MuOSM ) regulates the production of acute-phase proteins by hepatocytes as well as tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) production by fibroblasts in vitro
Sohara et al., J Hepatol 2002 (MAP Kinase Signaling System) : PD inhibited OSM mediated stimulation of TIMP-1 protein, mRNA, promoter activity, phosphorylation of MAPK, and TIMP-1 message stability ... An SP-1 transcription site of the TIMP-1 promoter is essential for OSM induction of TIMP-1 promoter activity
Hui et al., Arthritis Rheum 2003 (Osteoarthritis, Knee) : The in vivo data clearly indicated that OSM + TNFalpha overexpression increased MMP levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 )
Tong et al., Cell Signal 2004 : Mitogen activated protein kinases Erk1/2 and p38 are required for maximal regulation of TIMP-1 by oncostatin M in murine fibroblasts ... In mouse fibroblast cell lines MLg, NIH 3T3 and primary mouse lung fibroblasts ( MLF ), murine OSM ( muOSM ) stimulated high TIMP-1 mRNA expression in comparison to leukemia inhibitory factor (LIF), epidermal growth factor (EGF), interleukin (IL)-1beta and transforming growth factor ( TGF ) beta
Sanchez et al., Osteoarthritis Cartilage 2004 (Osteoarthritis, Knee) : In contrast, 10ng/ml OSM highly increased TIMP-1 production, and decreased by half the ratio MMP-3/TIMP-1
Weiss et al., J Mol Cell Cardiol 2005 : The gp130 ligand oncostatin M regulates tissue inhibitor of metalloproteinases-1 through ERK1/2 and p38 in human adult cardiac myocytes and in human adult cardiac fibroblasts : a possible role for the gp130/gp130 ligand system in the modulation of extracellular matrix degradation in the human heart ... The Erk1/2 inhibitor PD98059 and the p38 inhibitor SD202190 abolished the effect of OSM on TIMP-1 production in both cell types
Shingleton et al., Rheumatology (Oxford) 2006 : In primary human chondrocytes, RetA + OSM failed to induce MMP-1 or -13 but caused a significant increase in TIMP-1 expression
Fearon et al., Arthritis Rheum 2006 (Arthritis, Rheumatoid...) : In RA synovial explants, OSM induced production of MMP-1 and TIMP-1
Nemoto et al., Arthritis Rheum 1996 : Stimulation of TIMP-1 production by oncostatin M in human articular cartilage ... IL-6 family cytokines induced TIMP-1 expression in monolayer and explant culture, and the production of TIMP-1 was most stimulated by OSM
Gatsios et al., Eur J Biochem 1996 : Oncostatin M differentially regulates tissue inhibitors of metalloproteinases TIMP-1 and TIMP-3 gene expression in human synovial lining cells ... In contrast, oncostatin M , an interleukin-6-type cytokine produced by activated T-lymphocytes and monocytes, had a differential effect on TIMP mRNA levels
Malik et al., Matrix Biol 1995 : These results suggest that oncostatin M is a potent inducer of TIMP-1 and that its receptor mediated expression is conserved across species
Cawston et al., Arthritis Rheum 1998 (Arthritis, Rheumatoid...) : OSM increased the production of MMP-1 and TIMP-1 but when combined with IL-1alpha, synergistically promoted MMP-1 production in human chondrocytes and synovial fibroblasts