Wang et al., Oncogene 2003
(Breast Neoplasms) :
Treatment of ZR75 cultures with calcium+A23187 recapitulated the formation of the calcium/calpain induced LMW forms of cyclin E. Altered calcium homeostasis and/or inability of the endogenous calpain inhibitor to control the activity of high levels of the calpain small subunit may contribute to increased calpain activity in breast tumors, causing abundant levels of LMW cyclin E
Crespo-Biel et al., Neurosci Lett 2007
:
In this neurotoxic model, Western blot studies revealed that calpain activity increase was followed by changes in cyclin dependent kinase 5 (cdk5) and its activator p25
Lorca et al., EMBO J 1991
:
Cyclin proteolysis at micromolar free Ca2+, is not inhibited by calpastatin, and therefore does not involve calpain