Gene interactions and pathways from curated databases and text-mining

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AKT1 — PDK3

Text-mined interactions from Literome

Wen et al., Cell Signal 2003 : The increased Akt phosphorylation was blocked by phosphatidylinositol 3-kinase inhibitor wortmannin and the newly identified PIP ( 3 ) -dependent kinases ( PDK ) inhibitor SB 203580
Zou et al., Sheng li ke xue jin zhan [Progress in physiology] 2000 : PKB is also activated via phosphorylation by PDK and, in turn, will activate the anti-apoptotic machinery, glucose metabolism ( glycogen synthesis, glycolysis and glucose uptake ) and protein synthesis
Thimmaiah et al., J Biol Chem 2005 : Akt inhibitory phenoxazines did not inhibit the activity of recombinant phosphatidylinositol 3'-kinase, PDK1 , or SGK1 but potently inhibited the kinase activity of recombinant Akt and Akt deltaPH, a mutant lacking the pleckstrin homology domain
Zhang et al., Biochem Pharmacol 2007 (Prostatic Neoplasms) : In PC-3 cells, CMEP has been found to inhibit only AKT activation at both normal and serum-starvation conditions, not to inhibit PI3K, PDK1 , or MAPK
Lee et al., Mol Biol Cell 2009 (Alzheimer Disease) : In vitro experiments identified that beta-amyloid ( Abeta ), especially oligomer preparations, specifically interrupted the PDK dependent activation of Akt